猪急性脑内血肿状态下脑组织PO2,PCO2和pH的变化

目的：急性猪在急性脑内血肿所致颅内高压时，脑组织ＰＯ２、ＰＣＯ２、ｐＨ值的变化。方法：采用微量泵注射法建立猪急性脑内血肿模型，注血后连续监测平均动脉压（ＭＡＰ），颅内压（ＩＣＰ）、脑灌注压（ＣＰＰ），脑组织氧分压（ＰｔｉＯ２），脑组织二氧化碳分压（ＰｔｉＣＯ２），ｐＨ，ＨＣＯ３＾－及动脉血气的变化。结果：颅内注血后，ＩＣＰ急剧上升，ＣＰＰ下降，ＰｔｉＯ２下降（Ｐ〈０．０１），ＰｔｉＣＯ２升高（Ｐ〈

Changes PO2,PCO2 and pH during acute intracerebral hematoma in pig brain

Objective: To study the changes of the brain tissue PO 2,PCO 2 and pH during intracranial hypertension caused by intracerebral hematoma in pigs. Methods: The pig model of acute intracerebral hematoma was established by micropump method. MAP,ICP,CPP and brain tissue PO 2,PCO 2,pH,HCO 3 - were continuously monitored before, during and after blood injection. The arterial blood gas was analyzed. Results: After blood was injected, ICP was elevated significantly, CPP was decreased, P ti O 2 was decreased ( P <0.01),P ti CO 2 was elevated ( P <0.05), pH decreased ( P <0.05).There were good correletions between P ti O 2, CPP and ICP. Conclusion: Cerebral ischemia and hypoxia is detected after acute brain injury by brain tissue PO 2 monitoring,which can predict the outcome of patients with severe head injury. [