| 基质金属蛋白酶9与创伤性脑损伤 |
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| 引用本文： | 黄海能. 基质金属蛋白酶9与创伤性脑损伤[J]. 医学综述, 2009, 15(2): 164-166 |
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| 作者姓名： | 黄海能 |
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| 作者单位： | 右江民族医学院附属医院神经外科,广西百色,533000 |
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| 摘 要： | 基质金属蛋白酶系(MMPs)是脑损害特异性血清标志物,其中MMP-9的作用尤为重要。MMP-9可破坏血脑屏障,促进脑水肿形成,诱导脑创伤后神经细胞的死亡。基质金属蛋白酶抑制剂能抑制受激后脑内MMP-9的活性,减轻脑水肿的程度,有利于维持神经元生存微环境的稳定。MMP-9的表达水平有可能作为判断脑创伤发展和预后的指标。
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| 关 键 词： | 基质金属蛋白酶9 创伤性脑损伤 继发性脑损伤 |
Matrix Metalloproteinases-9 and Traumatic Brain Injury |
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| HUANG Hai-neng. Matrix Metalloproteinases-9 and Traumatic Brain Injury[J]. Medical Recapitulate, 2009, 15(2): 164-166 |
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| Authors: | HUANG Hai-neng |
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| Affiliation: | HUANG Hai-neng. ( Department of Neurosurgery,the Affiliated Hospital of Youjiang Medical College for Nationalities ,Baise 533000, China ) |
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| Abstract: | Matrix metalloproteinases （MMPs）are the brain-specific serum biomarkers. Matrix metalloproteinases -9 （MMP-9）is particularly important. MMP-9 can damage the blood-brain barrier, promote the brain edema and induce nerve cell after brain trauma to death. MMPs inhibitors can suppress the activity of MMP-9, alleviate cerebral edema,and maintain neuronal micro-environment. The level of MMP-9 may be used to assess the prognosis of pest-traumatic brain injury. |
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| Keywords: | Matrix metallooroteinases-9 ： Traumatic brain injury Secondary brain damage |
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