78例小儿急性髓系白血病的临床及疗效分析

探讨小儿急性髓系白血病的临床特点、治疗疗效及预后因素 ,对 1 991年 4月～ 2 0 0 0年 5月我院收治的 78例小儿急性髓系白血病进行临床总结和分析。结果显示 ,发病高峰为学龄儿童 ,男 :女 =2 :1 ,M2 型占 4 2 39%。治疗的 6 9例分别以四种方案化疗 ,完全缓解率 (CR) 6 3 76 % ;证明强诱导缓解方案对CR的进步、复发率的降低、生存率的提高有重要影响 ,治疗前的白细胞计数、肝脾肿大程度是影响诱导缓解的重要因素 ;治疗前心肌酶正常和CR所需时间短者预后较好。此外 ,化疗后的支持疗法和积极妥当的并发症处理 ,也是提高生存率的因素

ANALYSIS OF CLINICAL AND CURATIVE EFFECT OF 78 CASES OF CHILDHOOD ACUTE MYELOGENOUS LEUKEMIA

To identify the clicinal characteristics treatment responsivens and prognostic of infantile myelocytic leukemia. Seventy eight childhood acute myelocytic leukemias diagnosed from Apr.1991 to May. 2000 were retrospectively analyzed. Result shows that the peak time of the incidene is school age, male was predominantly, m 2 types were the largest portion occupying 42 30%. Seventy eight patients were received one of the four chemotherapeutical protocols, 63 76% of them has gotten complete remission. Condusions: our date suggest that early intensive chemotherapy is of key importance for archieving cures, the guicker the CR is achieved the more duration of CCR will be obtained.