Loss of NADPH-diaphorase containing neurones after reversible focal ischaemia in rats delayed by L-NAME. |
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| Authors: | I. Margaill M. Allix C. Charriaut-Marlangue R. G. Boulu M. Plotkine |
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| Affiliation: | Laboratoire de Pharmacologie, Université René Descartes, Paris, France. |
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| Abstract: | In the present study, NADPH-diaphorase histochemistry was used to assess the temporal evolution of the number of nitric oxide (NO)-synthase containing neurones after reversible focal cerebral ischaemia in rats. The number of NADPH-diaphorase containing neurones was reduced by 50% and 90% respectively 6 and 24 h after ischaemia. L-NAME, a NO-synthase inhibitor, prevented the loss of NADPH-diaphorase containing neurones observed 6 h after ischemia but not 24 h after ischaemia, suggesting that in the early phase, nitric oxide is involved in this phenomenon. |
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