Effect of low level fluoride on demineralization kinetics of human dental enamel |
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| Authors: | Takashi Nakano Celia Neale Colin Robinson Shoichi Sakakibara Shintaro Komoto Haruo Nakagaki Osamu Fukuta |
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| Institution: | 1. Department of Pediatric Dentistry, School of Dentistry, Aichi-Gakuin University 2-11 Suemori-dori, Chikusa-ku, Nagoya 464-8651, JAPAN;2. Division of Oral Biology, School of Dentistry, Leeds University Clarendon Way, Leeds LS2 9LU, UK;3. Department of Preventive Dentistry and Dental Public Health, School of Dentistry, Aichi-Gakuin University 1-100 Kusumoto-cho, Chikusa-ku, Nagoya 464-8650, JAPAN;1. Department of Dentistry for Children and Disabled Persons, Graduate School of Dental Medicine, Hokkaido University, Sapporo, Japan;2. Department of Biomaterials and Bioengineering, Graduate School of Dental Medicine, Hokkaido University, Sapporo, Japan;3. Department of Dentistry for Molecular Cell Pharmacology, Graduate School of Dental Medicine, Hokkaido University, Sapporo, Japan;1. Department of Pediatric Dentistry, Nihon University Graduate School of Dentistry at Matsudo, Matsudo, Chiba, Japan;2. Department of Pediatric Dentistry, Nihon University School of Dentistry at Matsudo, Matsudo, Chiba, Japan;3. Nihon University Research Institute of Oral Science, Chiba, Japan;1. Department of Pediatric Dentistry, School of Dentistry, Aichi-Gakuin University, Sumori-dori, Chikusa-ku, Nagoya, Japan;2. Department of Oral Anatomy, School of Dentistry, Aichi-Gakuin University, Kusumoto-cho, Chikusa-ku, Nagoya, Japan;3. Department of Preventive Dentistry and Dental Public Health, School of Dentistry, Aichi-Gakuin University, Kusumoto-cho, Chikusa-ku, Nagoya, Japan;1. Department of Pediatric Dentistry, Tokyo Dental College 1-2-2 Masago, Mihama-ku, Chiba 261-8502, JAPAN;2. Division of Pediatric Dentistry, Department of Clinical Oral Health Science, Tokyo Dental College 2-9-18 Misakicho, Chiyoda-ku, Tokyo 101-0061, JAPAN;3. Aoyama Dental Clinic 1-1-7 Shibuya, Shibuya-ku, Tokyo 150-0002, JAPAN |
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| Abstract: | The purpose of this study was to examine the effect of fluoride levels similar to those reported for saliva from low fluoridated and high fluoridated water areas on the demineralization of human permanent enamel. An adaptation of the method described by Robinson et al. was used. Sections of sound enamel were immersed in a vial containing demineralizing solution 2.0 mM Ca(NO3)2, 1.2 mM KHPO4 in 50 mM acetic acid, pH 4.8] for 1 hour. The demineralizing solution contained 0, 0.02 or 0.05 ppm fluoride, added as NaF was prepared. Twenty microliters aliquots were taken from the demineralizing solution at the time point up to 1 hour, with a sampling frequency bias towards the early time point. The phosphate content of the removed sample was determined by colorimetry. When the mineral loss curves for fluoridated and non-fluoridated demineralizing solutions were compared, there were significant differences between both groups. There was a decrease in the net mineral loss when fluoride was used. This result suggested that salivary fluoride levels of 0.02 ppm and 0.05 ppm had a protective effect against demineralization. |
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| Keywords: | Caries Demineralization Enamel Fluoride Saliva |
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