| 七龙天胶囊HPLC指纹图谱研究及4种成分的含量测定 |
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| 引用本文： | 付鹏,李江,李娇,彭霜,陈凌云,余晓玲. 七龙天胶囊HPLC指纹图谱研究及4种成分的含量测定[J]. 中华中医药杂志, 2021, 0(3): 1594-1597 |
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| 作者姓名： | 付鹏 李江 李娇 彭霜 陈凌云 余晓玲 |
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| 作者单位： | 云南中医药大学;云南省高校外用给药系统与制剂技术研究重点实验室;昆明市中医医院药剂科;云南中医药大学中药学院药剂教研室 |
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| 基金项目： | 国家自然科学基金项目(No.81860804);云南省科技厅重大项目(No.2018FA050)。 |
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| 摘 要： | 目的:建立七龙天胶囊HPLC指纹图谱分析方法,并同时测定红景天苷、三七皂苷R1、人参皂苷Rg1、人参皂苷Rb1的含量.方法:Diamonsil C18色谱柱(4.6mm×250mm,5μm);乙腈-水溶液梯度洗脱;检测波长:203nm;流速:1mL/min;进样量:10μL;温度:25℃.结果:15批七龙天胶囊的HPL...
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| 关 键 词： | 七龙天胶囊 指纹图谱 含量测定 红景天苷 三七皂苷R1 人参皂苷Rg1 人参皂苷Rb1 质量控制 |
Study on HPLC fingerprint of Qilongtian Capsule and content determination of four components |
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| FU Peng,LI Jiang,LI Jiao,PENG Shuang,CHEN Ling-yun,YU Xiao-ling. Study on HPLC fingerprint of Qilongtian Capsule and content determination of four components[J]. China Journal of Traditional Chinese Medicine and Pharmacy, 2021, 0(3): 1594-1597 |
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| Authors: | FU Peng LI Jiang LI Jiao PENG Shuang CHEN Ling-yun YU Xiao-ling |
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| Affiliation: | (Yunnan University or Chinese Medicine,Kunming 650500,China;Key Laboratory of Research on External Drug Delivery System and Preparation Technology in Colleges and Universities of Yunnan Province,Kunming 650500,China;Kunming Municipal Hospital of Traditional Chinese Medicine,Kunming 650500,China) |
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| Abstract: | Objective: To establish the HPLC fingerprint analysis method of Qilongtian Capsule, and the simultaneously determine contents of salidroside, notoginsenoside R1, ginsenoside Rg1 and ginsenoside Rb1. Methods: Diamonsil C18 column(4.6 mm×250 mm, 5μm);acetonitrile-water solution gradient elution;detection wavelength: 203 nm;flow rate: 1 mL/min;injection volume: 10μL;temperature: 25°C. Results: The 15 batches of Qilongtian Capsule had 11 common peaks in the HPLC spectrum, and the similarity was greater than 0.9. By comparing with the mixed control, 4 chemical components were identified, which were salidroside and notoginsenoside R1, Ginsenoside Rg1, Ginsenoside Rb1. The four components showed a good linear relationship within 46.2~595.3, 55.7~717.1, 46.9~604.0, 76.7~845.7μg/mL, and the average recovery was 99.53%~100.38%. Conclusion: This method is stable and feasible, and can be used for the quality control of Qilongtian Capsule. |
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| Keywords: | Qilongtian Capsule Fingerprint Content determination Salidroside Notoginsenoside R1 Ginsenoside Rg1 Ginsenoside Rb1 Quality control |
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