Towards a Pragmatic Alternative Testing Strategy for the Detection of Reproductive Toxicants |
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| Institution: | 1. Laboratory of Veterinary Biochemistry and Molecular Biology, College of Veterinary Medicine, Chungbuk National University, Cheongju, Chungbuk 28644, Republic of Korea;2. Department of Information and Statistics, College of Natural Sciences, Chungbuk National University, Cheongju, Chungbuk 28644, Republic of Korea;3. Toxicological Screening and Testing Division, National Institute of Food and Drug Safety Evaluation, Ministry of Food and Drug Safety, Cheongju, Chungbuk 28159, Republic of Korea;4. Predictive Model Research Center, Korea Institute of Toxicology, Daejeon 34114, Republic of Korea;5. Department of Human and Environmental Toxicology, University of Science and Technology, Daejeon 34113, Republic of Korea;6. Laboratory of Biochemistry and Immunology, College of Veterinary Medicine, Chungbuk National University, Cheongju, Chungbuk 28644, Republic of Korea;1. School of Integrative Biology, 505 South Goodwin Avenue, University of Illinois, Urbana, IL 61801, USA;2. School of Medicine, Medical Sciences and Nutrition. Institute of Medical Sciences, University of Aberdeen, Foresterhill, Aberdeen, AB25 2ZD, UK;3. Institute for Genomic Biology, 1206 W Gregory Drive, University of Illinois, Urbana, IL 61801, USA;1. College of Basic Medical Sciences, Zhejiang Chinese Medical University, Hangzhou, China;2. Department of Obstetrics & Gynaecology, The Chinese University of Hong Kong, Shatin, Hong Kong;3. Institute of Chinese Medicine & State Key Laboratory of Research on Bioactivities and Clinical Applications of Medicinal Plants, The Chinese University of Hong Kong, Shatin, Hong Kong;4. School of Nursing, Zhejiang Chinese Medical University, Hangzhou, China;5. IUF-Leibniz Research Institute of Environmental Medicine, Düsseldorf, Germany;6. Central Ethics Committee for Stem Cell Research (ZES), Robert Koch Institute, Berlin, Germany;7. Institute for Pharmacy, Faculty of Biology, Chemistry, and Pharmacy, Freie Universität, Berlin, Germany;8. School of Biomedical Sciences, The Chinese University of Hong Kong, Shatin, Hong Kong;9. Li Ka Shing Institute of Health Sciences, The Chinese University of Hong Kong, Shatin, Hong Kong |
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| Abstract: | Exposure of rodents in utero to perfluorooctane sulfonate (PFOS) impairs perinatal development and survival. Following intravenous or gavage exposure of C57Bl/6 mouse dams on gestational day (GD) 16 to 35S-PFOS (12.5 mg/kg), we determined the distribution in dams, fetuses (GD18 and GD20) and pups (postnatal day 1, PND1) employing whole-body autoradiography and liquid scintillation counting. In dams, levels were highest in liver and lungs. After placental transfer, 35S-PFOS was present on GD18 at 2–3 times higher levels in lungs, liver and kidneys than in maternal blood. In PND1 pups, levels in lungs were significantly higher than in GD18 fetuses. A heterogeneous distribution of 35S-PFOS was observed in brains of fetuses and pups, with levels higher than in maternal brain. This first demonstration of substantial localization of PFOS to both perinatal and adult lungs is consistent with evidence describing the lung as a target for the toxicity of PFOS at these ages. |
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