Emerging mitochondrial signaling mechanisms in physiology,aging processes,and as drug targets |
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| Authors: | Mahadevan Lakshminarasimhan Clemens Steegborn |
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| Institution: | 1. Department of Industrial and Food Microbiology, Faculty of Food Science, University of Warmia and Mazury in Olsztyn, Pl. Cieszyński 1, 10-726 Olsztyn, Poland;2. Department of Immunology and Food Microbiology, Institute of Animal Reproduction and Food Research, Polish Academy of Sciences, ul. Tuwima 10, 10-748 Olsztyn, Poland;1. Grupo de Seguridad y Calidad de los Alimentos por Bacterias Lácticas, Bacteriocinas y Probióticos (Grupo SEGABALBP), Departamento de Nutrición, Bromatología y Tecnología de los Alimentos, Facultad de Veterinaria, Universidad Complutense de Madrid, 28040, Madrid, Spain;2. Department of Genetics and Biotechnology, University of Trás-os-Montes and Alto Douro, 5001-801, Vila Real, Portugal;3. Servicio de Microbiología, Hospital Universitario Ramón y Cajal, Instituto Ramón y Cajal de Investigaciones Sanitarias (IRYCIS), 28034, Madrid, Spain;1. School of Food and Biological Engineering, Jiangsu University, 301 Xuefu Road, Zhenjiang, Jiangsu 212013, China;2. Key Laboratory for Physical Processing of Agricultural Products, Zhenjiang, Jiangsu 212013, China;3. Hospitality Department, School of Applied Science and Technology, Koforidua Polytechnic, Koforidua, Ghana;4. Department of Biological and Agricultural Engineering, University of California, Davis, One Shields Avenue, Davis, CA 95616, USA;1. Department of Neurobiology, Interdisciplinary Centre for Neurosciences (IZN), Heidelberg University, Heidelberg, Germany;2. Department of Cognitive Neuroscience, Donders Institute for Brain, Cognition and Behaviour, Radboud University Medical Center, Nijmegen, the Netherlands;3. Directors'' Research, European Molecular Biology Laboratory (EMBL), Heidelberg, Germany;4. Instituto de Medicina Molecular João Lobo Antunes, Faculdade de Medicina de Lisboa, Universidade de Lisboa, Lisbon, Portugal;1. College of Pharmacy, Jilin University, Changchun 130021, China;2. State Key Laboratory of Respiratory Diseases, Guangzhou Institutes of Biomedicine and Health, Chinese Academy of Sciences, #190 Kaiyuan Avenue, Guangzhou 510530, China;3. University of Chinese Academy of Sciences, #19 Yuquan Road, Beijing 100049, China;4. School of Pharmacy, Jinan University, 601 Huangpu Avenue West, Guangzhou 510632, China |
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| Abstract: | Advances in research on mitochondria have elucidated their importance in cell survival and cell death regulation in addition to their function in energy production. Mitochondria are further implicated in various metabolic and aging-related diseases, which are now assumed to be caused by misregulation of physiological systems rather than pure accumulation of oxidative damage. Thus, the signaling mechanisms within mitochondria and between the organelle and its environment have gained interest as potential drug targets. Emerging mitochondrial signaling systems with potential for exploiting them for therapeutic intervention include, among others, the NAD+-dependent protein deacetylases of the Sirtuin family, the redox enzyme p66Shc, and enzymes of the cyclic adenosine monophosphate (cAMP) signaling pathways. Here, we discuss functions of these signaling systems in mitochondria, their roles in aging processes and disease, and their potential to serve as therapeutic targets. |
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