不同性别非冠状动脉阻塞性胸痛患者冠状动脉血流储备特点及影响因素研究

目的 探讨不同性别非冠状动脉阻塞性胸痛患者冠脉血流储备的特点及影响因素.方法 入选2011年10月至2017年9月于北京大学第三医院心内科就诊的302例影像学检查证实冠脉狭窄＜50％的胸痛患者,行经胸多普勒超声心动图测定冠状动脉左前降支的冠脉血流储备(CFR),比较男女性CFR特点.结果 研究对象平均年龄(60.1±9...

Characteristics and influencing factors of coronary flow reserve in patients of different gender with chest pain without obstructive coronary artery disease

Objective To study the characteristics and influencing factors of coronary flow reserve(CFR)in different gender with chest pain with non-obstructive coronary artery disease. Methods From October 2011 to September 2017,302 patients with chest pain whose coronary stenosis was less than 50% confirmed by CAG or CTA in the Department of Cardiology,Peking University Third Hospital were enrolled. CFR in left anterior descending coronary artery was measured by transthoracic Doppler echocardiography. Analyze the characteristics and influencing factors of CFR in different gender.Results The average age of the patients was(60.1+9.1)years,male 117(38.7%),and female 185(61.3%). The overall CFR was 2.92+0.64,and CFR was lower in female than in male[(2.86+0.62)vs.(3.02+0.67),P=0.039]. The overall incidence of CMD with CFR<2.5 was 25.5%,and there was no statistically significant difference in the incidence of CMD between male and female(P>0.05). Multivariate linear analysis showed that age,history of hypertension and smoking were independent influencing factors of the male CFR,while age and BMI were the independent influencing factors of the female CFR(P<0.05). Conclusion CFR in chest pain patients with non-obstructive coronary artery disease is lower in women than in men,but there is no difference in theincidence of CMD. Age,hypertension history andsmoking are independent factors of the male CFR,while age and BMI are independent factors of thefemale CFR.