| 肉豆蔻的炮制工艺优化对蒙药肉豆蔻五味中黄樟醚含量的影响 |
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| 引用本文： | 闫婷婷,贾鑫,朱小玲,赵忆宁,王晓雪,王玥璇,赵洪超,董玉. 肉豆蔻的炮制工艺优化对蒙药肉豆蔻五味中黄樟醚含量的影响[J]. 中华中医药杂志, 2021, 0(3): 1598-1602 |
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| 作者姓名： | 闫婷婷 贾鑫 朱小玲 赵忆宁 王晓雪 王玥璇 赵洪超 董玉 |
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| 作者单位： | 内蒙古医科大学药学院;内蒙古自治区蒙药药效物质与质量控制工程技术研究中心;内蒙古医科大学附属医院药剂部;内蒙古自治区国际蒙医医院药学部;内蒙古医科大学金山校区药学院 |
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| 基金项目： | 2019年内蒙古自治区科技计划项目,内蒙古自治区草原英才创新团队滚动支持项目,蒙药药效物质与质量控制工程技术研究中心项目。 |
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| 摘 要： | 目的:通过优化肉豆蔻的炮制工艺,分析炮制对蒙药肉豆蔻五味中黄樟醚的影响.方法:以黄樟醚的含量为指标,采用气相色谱结合正交试验法优选肉豆蔻的炮制工艺,考察炮制前后蒙药肉豆蔻五味中黄樟醚含量的变化.结果:黄樟醚在0.504～1.134μg(r=0.9995)有良好线性关系,平均回收率为99.6％,RSD为1.8％.正交试验...
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| 关 键 词： | 蒙药肉豆蔻五味 炮制 黄樟醚 气相色谱法 正交试验 |
Effects of processing optimization of nutmeg on safrole content in Mongolian medicine Nutmeg-5 |
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| YAN Ting-ting,JIA Xin,ZHU Xiao-ling,ZHAO Yi-ning,WANG Xiao-xue,WANG Yue-xuan,ZHAO Hong-chao,DONG Yu. Effects of processing optimization of nutmeg on safrole content in Mongolian medicine Nutmeg-5[J]. China Journal of Traditional Chinese Medicine and Pharmacy, 2021, 0(3): 1598-1602 |
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| Authors: | YAN Ting-ting JIA Xin ZHU Xiao-ling ZHAO Yi-ning WANG Xiao-xue WANG Yue-xuan ZHAO Hong-chao DONG Yu |
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| Affiliation: | (College of Pharmacy,Inner Mongolia Medical University,Hohhot 010059,China;Engineering Technology Research Center of Pharmacodynamic Substance and Quality Control of Mongolian Medicine in Inner Mongolia,Hohhot 010110,China;Department of Pharmacy,The Affiliated Hospital of Inner Mongolia Medical University,Hohhot 010059,China;Department of Pharmacy,Inner Mongolia International Mongolian Hospital,Hohhot 010065,China) |
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| Abstract: | Objective: To analyze the effects of processing on the Mongolian medicine Nutmeg-5 by optimizing the processing technology of nutmeg. Methods: The content of safrole as an index, gas chromatography combined with orthogonal test was used to optimize the processing technology of nutmeg, and the changes in the content of safrole in the Mongolian medicine Nutmeg-5 before and after processing were investigated. Results: There was a good linear relationship of safrole between 0.504~1.134μg(r=0.9995). The average recovery rate was 99.6%, RSD was 1.8%. Orthogonal test results showed that the best processing technology of nutmeg was sand blanching, 6 h, 2 times. After processing, the content of safrole in Mongolian medicine Nutmeg-5 was 0.027%, and the content of safrole dropped by more than 20%. Conclusion: The established gas chromatography method can be used to determine the content of safrole in the Mongolian medicine Nutmeg-5. The preferred nutmeg processing method is stable and reliable. It can significantly reduce the content of safrole in the Mongolian medicine Nutmeg-5 and achieve the effect of ’decreasing poison and increasing efficiency’. |
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| Keywords: | Mongolian medicine Nutmeg-5 Processing Safrole Gas chromatography Orthogonal test |
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