Percutaneous Interventions in Radiation-Associated Coronary
In-Stent Restenosis |
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Authors: | Email author" target="_blank">P?WexbergEmail author G?Beran I?Lang P?Siostrzonek C?Kirisits D?Glogar M?Gottsauner-Wolf |
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Institution: | (1) Division of Cardiology, Department of Internal Medicine II, University of Vienna, Austria;(2) Division of Medical Radiation Physics, Department of Radiotherapy and Radiobiology, University of Vienna, Austria |
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Abstract: | This study was performed to evaluate the outcome of
percutaneous revascularization in edge restenoses developing
after radioactive stent implantation in de novo and in-stent
lesions. Twenty-one consecutive patients undergoing target lesion
revascularization (TLR) at any follow-up after phosphorus-32
radioactive stent implantation were included in this study. We assessed
the incidence of death, myocardial infarction, repeated TLR and
recurrent angina over the following 18 months. After 6 months, TLR rate
was 28.6%, and no stent thromboses, deaths or Q-wave myocardial
infarctions occurred. Among the patients with TLR there were
significantly more subjects who had received a radioactive stent in a
previous in-stent restenosis (66.7% vs. 0% in patients without second
restenosis; P < 0.001), or who had received two
radioactive stents (83.3% vs. 33.3%; P = 0.038).
After 18 months, TLR rate was 33.3%, and two patients (9.5%) had
died. Restenosis after intravascular radiotherapy can be safely treated
by percutaneous interventional techniques, yielding an acceptable
clinical result within 18 months. |
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Keywords: | Coronary artery disease Intravascular brachytherapy Percutaneous coronary intervention Restenosis |
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