| 尼古丁对大鼠局灶性脑缺血再灌注损伤的神经保护作用 |
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| 引用本文： | 陈宇,桑韩飞,马丽,霍婷婷,熊利泽.尼古丁对大鼠局灶性脑缺血再灌注损伤的神经保护作用[J].神经解剖学杂志,2010,26(5). |
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| 作者姓名： | 陈宇 桑韩飞 马丽 霍婷婷 熊利泽 |
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| 作者单位： | 第四军医大学西京医院麻醉科,西安,710032 |
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| 基金项目： | 国家自然科学基金杰出青年科学基金，国家自然科学基金青年科学基金 |
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| 摘 要： | 目的:研究尼古丁对大鼠局灶性脑缺血再灌注损伤是否具有神经保护作用。方法:在大鼠大脑中动脉堵塞(MCAO)前30min给予腹腔注射尼古丁酒石酸盐溶液,观察局灶性脑缺血2h再灌注24h后,大鼠神经行为学评分及脑梗死容积的变化。结果:再灌注24h后,与单纯缺血再灌注组相比,给予尼古丁酒石酸盐溶液注射可以改善动物的神经行为学评分、减少脑梗死容积百分比(P0.05)。结论:尼古丁对大鼠局灶性脑缺血再灌注损伤具有神经保护作用。
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| 关 键 词： | 尼古丁 局灶性脑缺血再灌注 神经保护 大鼠 |
The neuroprotection of nicotine to the cerebral ischemia/reperfusion injury of rats |
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| Chen Yu,song Hanfei,Ma Li,Huo Tingting,Xiong Lize.The neuroprotection of nicotine to the cerebral ischemia/reperfusion injury of rats[J].Chinese Journal of Neuroanatomy,2010,26(5). |
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| Authors: | Chen Yu song Hanfei Ma Li Huo Tingting Xiong Lize |
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| Institution: | Chen Yu,Sang Hanfei,Ma Li,Huo Tingting,Xiong Lize(Department of Anesthesiology,Xijing Hospital,Fourth Military Medical University,Xi'an 710032,China) |
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| Abstract: | Objective:To explore whether nicotine has a neuroprotective effect on the focal cerebral ischemia/reperfusion(I/R)injury in rats.Methods:Thirty min after the injection of nicotine ditartrate,focal cerebral ischemia was induced by middle cerebral artery occlusion(MCAO)for 120 min in male Sprague-Dawley rats.The neurobehavioral scores,infarct volumes were evaluated at 24 h of reperfusion.Results:After 24 h of reperfusion,nicotine ditartrate injection improved neurological outcome and reduced infarct size(P<0.... |
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| Keywords: | nicotine middle cerebral artery occlusion neuroprotection rat |
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