High-dose Gd-DTPA vs. Bis-Gd-mesoporphyrin for monitoring laser-induced tissue necrosis |
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Authors: | Bremer Christoph Bankert Joerg Filler Timm Ebert Wolfgang Tombach Bernd Reimer Peter |
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Institution: | Department of Clinical Radiology, University of Muenster, Muenster, Germany. bremerc@uni-muenster.de |
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Abstract: | PURPOSE: To compare Bis-Gd-mesoporphyrin (Bis-Gd-MP), a contrast agent with a reported high affinity to necrotic tissue, with high-dose gadopentate dimeglumin (Gd-DTPA) for defining laser-induced muscle and liver necrosis by contrast-enhanced (CE) MRI. MATERIALS AND METHODS: Laser-induced interstitial thermotherapy (LITT) was performed in the muscle and liver tissue of New Zealand White rabbits (1500 J and 2100 J; n=80 lesions). The animals were randomly assigned to a group that received 0.3 mmol/kg bw Gd-DTPA or a group that received 0.05 mmol/kg bw Bis-Gd-MP. Following contrast injection, dynamic MRI was performed on muscle lesions with a T1-weighted, two-dimensional, fast low-angle shot (FLASH) sequence. The liver and muscle lesions were then repeatedly imaged for six hours after contrast injection using a T1-weighted spin-echo (SE) sequence. Central and peripheral lesion enhancement was determined and correlated with gross pathology and microscopy findings. RESULTS: Both contrast agents allowed precise determination of lesion diameters with an average accuracy of 6.8%+/-1.3%. Rim enhancement during dynamic MRI was superior for Gd-DTPA (P<0.001) and revealed slightly higher lesion diameters compared to the results of follow-up MR studies. A persistent enhancement of necrotic liver and muscle tissue was observed for both contrast agents throughout the observation period, suggesting that simple diffusion-type processes may underlie the supposed affinity of Bis-Gd-MP for tissue necrosis. CONCLUSION: Bis-Gd-MP and Gd-DTPA are equally well suited for postinterventional lesion assessment in LITT. |
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Keywords: | laser‐induced interstitial thermotherapy LITT MRI contrast agents Gd‐DTPA Bis‐Gd‐mesoporphyrin gadophrin‐2 necrosis |
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