| 氨基胍对糖尿病大鼠视网膜微细结构改变的影响 |
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| 引用本文： | 孟德欣,杨笑天,张涤,王显刚,栾海燕. 氨基胍对糖尿病大鼠视网膜微细结构改变的影响[J]. 黑龙江医药科学, 2005, 28(2): 10-11 |
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| 作者姓名： | 孟德欣 杨笑天 张涤 王显刚 栾海燕 |
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| 作者单位： | 佳木斯大学基础医学院,黑龙江,佳木斯,154007;佳木斯大学第一附属医院,黑龙江,佳木斯,154002 |
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| 摘 要： | 目的:探讨氨基胍对糖尿病大鼠视网膜病变的防治作用及其机理。方法:选择健康成年Wistar大鼠36只,体重180～2 2 0 g,随机分成正常组、模型组、治疗组,模型组和治疗组大鼠尾静脉注射四氧嘧啶(5 0 mg/ kg)造成糖尿病模型,治疗组腹腔注射氨基胍(80 m g/ kg.d)治疗10周,各组分别测糖化血红蛋白,制备视网膜光镜切片PAS染色镜下观察。结果:治疗组糖化血红蛋白含量明显低于模型组,光镜下观察可见周细胞的变化。结论:氨基胍对糖尿病大鼠视网膜病变具有良好的保护作用,这可能与其抑制非酶蛋白质糖基化等有关
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| 关 键 词： | 糖尿病 糖尿病视网膜病变 氨基胍 |
| 文章编号： | 1008-0104(2005)02-0010-01 |
| 修稿时间： | 2005-03-02 |
Effect of aminoguanidine on retinal fine structural change in diabetic rats |
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| MENG De-xin,YANG Xiao-tian,ZHANG Di,WANG Xian-gang,LUAN Hai-yan. Effect of aminoguanidine on retinal fine structural change in diabetic rats[J]. Heilongjiang Medicine and Pharmacy, 2005, 28(2): 10-11 |
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| Authors: | MENG De-xin YANG Xiao-tian ZHANG Di WANG Xian-gang LUAN Hai-yan |
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| Affiliation: | MENG De-xin1,YANG Xiao-tian2,ZHANG Di2,WANG Xian-gang1,LUAN Hai-yan1 |
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| Abstract: | Objective: To study the effect of aminoguanidine in di ab etic retinopathy rats. Methods: Thirty-six Wistar rats, weighted 1 80~220g,were divided into the normal group, model group and treatment group. The model group and the treatment group were injected with alloxan (50mg/kg) in the vena caudalis to prepare diabetic models. The treatment group was injected with aminoguanidine (80mg/kg) in the abdominal cavity for 10 weeks. The glycosylated hemoglobin ( GHb ) was detected in every group and the retina was observed with microscope. Results: The GHb of the treatment group was markedly lower than that of the model group, with the change of mural cell found with mic roscope. Conclusion: Aminoguanidine can play a protective role in the diabetic retinopathy rats, which might be related to its inhibition of AGEs. |
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| Keywords: | diabetes diabetic retinopathy aminoguanidine |
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