ASSESSING THE RESECTABILITY OF PANCREATIC DUCTAL ADENOCARCINOMA:COMPARISION OF DUAL- PHASE HELICAL CT ARTERIAL PORTOGRAPHY WITH CONVENTIONAL ANGIOGRAPHY

INTRODUCTION Pancreatic cancer continues to present a diagnostic and therapeutic challenge. Its morbidity is still rising and the prognosis is dismal in spite of continuing improvements of imaging modalities and treatment. So far, surgical resection represents the only known method of curing pancreatic cancer. Because of high perioperative morbidity rate(20％～ 30％ ) of laparotomy in such patients,careful patient selection predicted on accurate disease staging is of prime importance(1,2)…

ASSESSING THE RESECTABILITY OF PANCREATIC DUCTAL ADENOCARCINOMA:COMPARISION OF DUAL-PHASE HELICAL CT ARTERIAL PORTOGRAPHY WITH CONVENTIONAL ANGIOGRAPHY

Objective. To evaluate the respective value of dual-phase helical CT arterial portography (CTAP) and conventional angiography in preoperative predicting resectability of pancreatic ductal adenocarcinoma. Subjects and methods. Tumor resectability was prospectively evaluated in 54 patients with pathologically proven pancreatic ductal adenocarcinoma who later underwent surgery. Both dual-phase helical CT scanning and selective angiography were obtained in each patient preoperatively. For optimal enhancement of pancreas and major peripancreatic vessels, two catheters connected to an automatic injector via a Y-shaped tube were placed after selective angiography,one in celiac trunk, the other in superior mesenteric artery. Then the patient underwent dual-phase helical CTAP of pancreas and liver. The criteria of irresectability for CTAP include: tumor diameter≥ 5 cm,extrapancreatic invasion, distant metastases and vascular involvement(occlusion, stenosis or semicircular encasement of superior mesenteric artery, hepatic artery, splenic artery, celiac axis; portal vein, superior mesenteric vein or splenic vein). The results of both modalities were correlated with findings from surgery or pathology. Results. Thirty-eight of 54 patients had nonresectable disease. In prediction the irresectability, sensitivity, specificity, positive predictive value, negative predictive value and overall accuracy were 94.7％ ,100％ ,100％ ,88.9％ ,96.3％ respectively for helical CTAP and 63.2％ ,93.8％ ,96.0％ ,51.7％ ,72.2％ respectively for selective angiography. In assessing vascular involvements, dual-phase helical CTAP was also superior to selective angiography. Conclusion. Dual-phase helical CTAP is superior to angiography in assessing resectability of pancreatic ductal adenocarcinoma. The combination of the two modalities may further improve overall accuracy of assessment.