非那雄胺对前列腺增生症术中及术后出血的治疗作用

目的：探讨非雄胺（保列治）对前列腺增生症术中和术后出血的疗效及机制。方法：应用免疫组化S－P法检测43例服药组和46例未服药组前列腺组织中CD34、bcl-2、PCNA和VEGF的表达。分析比较二组临床资料及免疫组化指标。结果：服药组术中输血人数、输血量及术后继发性血尿的发生率较对照组均明显减少，两组间差别有显著性意义（P＜0．05）。免疫组化结果显示前列腺组织中血管密度及血管内面积较对照组明显减少，两组差别有非常显著性意义（P＜0．01）。两组前列腺组织中bcl-2、PCNA和VEGF阳性表达率差别有显著性意义（P＜0．01），表现为服药组较未服药组明显减弱。结论：非那雄胺通过抑制前列腺组织中微血管形成，已形成血管的收缩，促进凋亡，抑制EGF合成和前列腺增殖而防止和减少术中及术后出血。

The effect of finasteride on bleeding associated with suprapubic prostatectomy and transurethral resection of prostate

Objective To study the effect of finasteride on bleeding associated with suprapubic prostatectomy and transurethral resection of prostate (TURP). Methods CD 34 ,bcl-2,PCNA and VEGF expressions in the prostatic tissues were studied by means of immunohistochemical method in 89 patients undergone prostatectomy,43 of them had taken fenateride and the other 46 did not.Acomparative study of clinical data and immunohistochemical parameters was made between the 2 groups. Results The volume of bleeding and blood transfusion needed were much less in the group treated with fenasteride.The microyascular density as studied by immunohistochemistry was much less in the fenasteride group.The expressions of bcl-2,PCNA and VEGF were also different between the 2 groups ( P <0.001). Conclusions Finasteride suppresses angiogenesis,VEGF synthesis,prostatic hyperplasia and promotes apoptosis.So,it might lessen prostatic bleeding associated with prostatectomy.