Intraoperative radiotherapy for resectable and unresectable pancreatic carcinoma |
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Authors: | Akimasa Nakao Akio Harada Toshiaki Nonami Tetsuya Kaneko Soichiro Inoue and Hiroshi Takagi |
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Institution: | (1) Second Department of Surgery, Nagoya University School of Medicine, 65 Tsurumai-cho, Showa-ku, 466 Nagoya, Aichi, Japan |
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Abstract: | Eighty patients with pancreatic carcinoma were treated by intraoperative radiotherapy (IORT) with or without surgical resection
of the tumor, and the results were compared with those of 111 patients treated by surgery alone. For resectable patients,
the radiation dose was 30 Gy and the average field sizes were 8 or 10 cm; for unresectable patients, these values were 20–30
Gy and 6 or 8 cm, respectively. No side effects of IORT were observed. In 49 resectable stage III patients, the IORT group
(n=16) had a higher survival rate than the non-IORT group (n=33); i.e., 1-year survival rates of 44.6% vs 23% and 2-year survival rates of 37.2% vs 7.7% after surgery (P<0.05). However, there was no significant difference in survival rate between the IORT group (n=28) and the non-IORT group (n=29) in 57 resectable patients in stage IV. In unresectable patients, the IORT group (n=31) (P<0.05) had a higher survival rate than the non-IORT group (n=38) (P<0.05). The palliative effect of IORT on abdominal or back pain was evaluated in 15 patients who had such symptoms and did
not undergo tumor resection. Overall, pain decreased or disappeared in 13 of these patients (87%).
Offprint requests to: A. Nakao |
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Keywords: | pancreatic carcinoma radiotherapy intraoperative radiotherapy resection non-resection |
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