| +Gz作用下兔心脏功能的改变 |
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| 引用本文： | 孙喜庆,蔡建辉,刘勇,薛立军,孙会品.+Gz作用下兔心脏功能的改变[J].航天医学与医学工程,1997(4). |
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| 作者姓名： | 孙喜庆 蔡建辉 刘勇 薛立军 孙会品 |
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| 作者单位： | 第四军医大学航空生物动力学教研室，第四军医大学西京医院胸心外科 |
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| 摘 要： | 为观察＋Ｇｚ作用下兔心脏功能的改变，７只新西兰兔经麻醉后依次分别暴露于＋２、＋４和＋６Ｇｚ，峰值持续时间为３０ｓ，增长率为１Ｇ／ｓ，每次暴露后恢复时间为１５ｍｉｎ。记录左心室内压、左心室内压变化速率、心电图等的变化。在＋２、＋４和＋６Ｇｚ作用下，左心室内压峰值较暴露前对照值分别降低６２．９６％（Ｐ＜０．０１）、６３．３４％（Ｐ＜０．０１）及８２．０１％（Ｐ＜０．０１），左心室内压最大上升速率分别降低５８．４６％（Ｐ＜０．０１）、５３．５９％（Ｐ＜０．０１）及６３．０６％（Ｐ＜０．０１），左心室舒张末压分别降低６７．７８％（Ｐ＞０．０５）、３３２．７４％（Ｐ＜０．０１）及５００．５４％（Ｐ＜０．０１）。除ＰｖＣＯ２在＋６Ｇｚ作用后即刻显著升高外（Ｐ＜０．０５），其余动、静脉血气结果在＋Ｇｚ作用后即刻较暴露前对照值均无显著性变化。＋Ｇｚ作用可引起兔心脏泵血功能显著降低。
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| 关 键 词： | 正加速度 加速度应激（生理 ）心功能 心肌收缩 兔 |
Changes of Cardiac Function During +Gz Exposure in Rabbits. |
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| SUN Xiqing,CAI Jianhui,LIU Yong,XUE Lijun,SUN Huipin..Changes of Cardiac Function During +Gz Exposure in Rabbits.[J].Space Medicine & Medical Engineering,1997(4). |
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| Authors: | SUN Xiqing CAI Jianhui LIU Yong XUE Lijun SUN Huipin |
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| Abstract: | Changes of cardiac function was studied during+Gz exposure in rabbits.Seven New Zealand rabbits were anesthetized and exposed to +2, +4, and +6 Gz (each for 30s, onset rate 1G/s, with 15 min interval in between). The left ventricular systolic pressure(LVSP),peak rate of left ventricular pressure rising(+dp/dt max ) and ECG were recorded. The results showed that during +2,+4 and +6 Gz exposures, LVSP decreased by 62.96% (P<0.01), 63.34% (P<0.01) and 82.01%(P<0.01) respectively, and +dp/dt max decreased by 58.46%(P<0.01), 53.59%(P<0.01) and 63.06%(P<0.01) respectively, and the left ventricular end diastolic pressure decreased by 67.78%(P>0.05), 332.74%(P<0.01) and 500.54%(P<0.01) respectively, as compared with those of control. It is suggested that cardiac function is depressed with +Gz exposure. |
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| Keywords: | positive acceleration acceleration stress(physiology) cardiac function myocardial contruction rabbit |
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