C-met蛋白和Ki-67在子宫内膜癌组织中的表达及意义

目的：研究肝细胞生长因子（HGF）受体C-met蛋白与细胞增殖核抗原Ki-67在子宫内膜癌中的表达及二者的关系，探讨其在子宫内膜癌发病中的意义。方法：应用免疫组织化学Envision法对41例子宫内膜癌、17例子宫内膜非典型增生及35例子宫增生期内膜组织中C-met蛋白和Ki-67表达进行检测，并对子宫内膜癌组的分化程度、手术-病理分期、肌层浸润、淋巴结转移的临床情况进行分析。结果：C-met及Ki-67在子宫内膜非典型增生的表达高于正常增生期内膜，在子宫内膜癌中的表达又高于子宫内膜非典型增生，有显著性差异（P〈0．05）；在子宫内膜癌中C-met与Ki-67密切正相关（r〈1，P〈0．01），且均与子宫内膜癌分化程度、手术-病理分期相关（P〈0．05）。结论：C-met蛋白和Ki-67在子宫内膜癌中的表达明显增高，二者呈正相关性，可能共同促进肿瘤细胞的增殖、分化，对子宫内膜癌的发生、发展具有重要作用，并可能成为判断子宫内膜癌预后的重要指标。

The Expression of C-met Protein and Ki-97 in Endometrial Carcinoma and Their Clinical Significance

Objective: To study the distribution and expression of hepatocyte growth factor receptor(C-met) protein and cell generation nuclear antigen(Ki-67) in endometrial carcinoma and their relationship.Methods: Expression of C-met and Ki-67 were detected in tissue of 41 cases of endometrial carcinoma,17 cases of atypical hyperplasia,and 35 cases of normal endometrium by immunohistochemical envision assay.The relativity of endometrial carcinoma with clinico-pathologic feature and prognosis was analyzed.Results: The expression of C-met and Ki-67 in atypical hyperplsia was higher than that in normal endometrium,and it was even higher in endometrial carcinoma than that in atypical hyperplsia(P<0.05).In endometrial carcinoma,the expression of C-met was significantly correlated with Ki-67(r<1,P<0.01).The expression of C-met and Ki-67 were related to endometrial carcinoma differentiation degree,and operation-pathological stages(P<0.05).Conclusions: C-met and Ki-67 express strongly in endometrial carcinoma.There is a positive correlation between the expression of C-met and Ki-67.They might promote cell proliferation,motility and contribute to the progression of endometrial carcinoma.The expression and collocation of C-met and Ki-67 can be used as two useful prognostic factors of endometrial carcinoma.