4种肿瘤标志物对上皮性卵巢癌定性诊断价值的初步研究

目的：探讨多胺（ＰＡ）、ＣＡ１２５、ＣＡ１５．３和ＣＡ１９．９在定性诊断上皮性卵巢癌中的价值。方法：应用ＨＰ％Ｍ高效液相色谱仪和ＨＰ１０４０Ａ荧光检测器或酶联免疫吸附法测定上皮性卵巢癌４０例和卵巢良性肿瘤１８例血清中ＰＡ、ＣＡ１２５、ＣＡ１５．３和ＣＡ１９．９水平。结果：４种标志物中，ＰＡ诊断卵巢癌的敏感性、阳性预测率、阴性预测率和预测准确率最高，其次是ＣＡ１２５。结论：ＰＡ对人类恶性肿瘤缺乏特异性，但可作为鉴别卵巢良、恶性病变的有价值标志物。联合测定ＰＡ和ＣＡ１２５时，其敏感率为９４．９％。因此，联合测定ＰＡ和ＣＡ１２５可作为筛查卵巢良、恶性肿瘤的方法。

Study on four tumor markers for diagnostic quality of ovarian epithelial carcinoma.

Objective To study the value of polyamine(PA),CA 125 CA 15.3 and CA 19.9 for diagnosis of ovarian cancer. Methods Serum levels of PA,CA 125 , CA 15.3 and CA 19.9 in 36 patients with ovarian cancers and 18 patients with ovarian benign tumors were determined by using HP 10% M high liquid chromatography and ELISA. Results PA had the highest sensitivity,positive predictibility,negative predictibility and predictable accuracy for diagnoses of ovarian cancer among the four tumor markers.CA 125 was the second good tumor marker. Conclusions 1.PA lacks the specificity for diagnosis of human malignancies,however,it would be used as a tumor marker to differentiate ovarian cancers from women with benign pelvic masses.2.Combined determination of PA with CA 125 ,the sensitivity for diagnosis of ovarian cancer will be 94.4%.Therefore combined determination of PA with CA 125 would be used as an valuable screening method for suspected ovarian masses.