20例原发性输卵管癌组织中ER、PR与p~(53)蛋白的表达

目的：分析原发性输卵管腺癌的ＥＲ、ＰＲ及ｐ５３蛋白的表达，研究其与该肿瘤的临床分期、病理分级及患者预后的关系。方法：材料选自２０份原发性输卵管腺癌及１０份正常输卵管组织的存档石蜡包埋标本，采用免疫组化法检测。结果：在２０份原发性输卵管癌标本中，ＥＲ、ＰＲ的阳性表达率分别为２５％和１５％，稍高于正常输卵管组的１０％，但差异无显著性（Ｐ＞０．０５）；ｐ５３蛋白在癌症组的阳性表达率为４０％，对照组则无１例阳性表达，差异有显著性（Ｐ＜０．０５）；ｐ５３蛋白在晚期、分化差及预后不良的输卵管癌病例中的表达呈上升趋势，但未达到统计学意义（Ｐ＞０．０５）；对侧输卵管炎症的存在与ｐ５３蛋白的阳性表达呈负相关（Ｐ＜０．０５）。结论：在原发性输卵管癌中，ＥＲ、ＰＲ有一定程度的表达，但均较低；ｐ５３基因的突变可能参与了该肿瘤的发生，并可作为综合判断其恶性程度及患者预后的指标之一。

Expressions of ER,PR and p53 gene protein in 20 primary fallopian tube carcinomas

Objectives:To study and to analyse the expressions of ER,PR and p53 protein in primary fallopian tube carcinoma.Methods:Expressions of ER,PR and p53 protein in 10 specimens of normal fallopian tubes and 20 specimens of primary fallopian tube carcinomas were determined by immunohistochemical technique. Results:ER positive rate and PR positive rate were 25% and 15% respectively in carcinoma group,but in contral group,they were both 10% (P>0.05).In carcinoma group,the overexpression of p53 protein was found in 40% specimens,and in normal group no positive was found(P<0.05).In poor prognosis group,expression of p53 protein showed an elevated tendency,but had no statistical significance(P>0.05).It indicated a negative relation between the expression of p53 protein and the oppositive salpingitis(P<0.05).Conclusions:In primary fallopian tube carcinomas,the expressions of ER,PR are very low; p53 gene protein may be related to the oncogenesis of primary fallopian tube carcinoma,and it can be used to judge the patients' prognosis.