食管癌患者外周血中基质活检因子mRNA表达的临床意义

 【摘要】　目的　探讨食管癌患者外周血中基质活检因子（MMP-7）mRNA 表达与食管癌复发及预后的关系。方法　采用实时荧光定量RT-PCR方法，检测82例食管癌术后患者外周血中MMP-7 mRNA表达。结果　82例食管癌患者中，MMP-7 mRNA 表达阳性率为37.5 %。MMP-7 mRNA 表达阳性与淋巴结转移、血行转移和临床分期显著相关。28例复发患者中，15例接受动态观察，其中5例外周血中MMP-7 mRNA 表达阳性先于影像学3～6个月，8例同时阳性。结论　食管癌患者外周血中MMP-7 mRNA 表达阳性可作为食管癌转移、复发和预后判断的指标。

Effects of MMP-7 mRNA expression in esophageal cancer

【Abstract】　Objective　To investigate the relationship between the expression of MMP-7 in peripher－al blood and esophageal cancer. Methods　By using Real time RT-PCR, blood samples from 82 cases with postoperative esophageal cancer were detected. Results　37.8 %（32/82） patients were positive for MMP-7 mRNA expression. MMP-7 mRNA positivity significantly correlated with lymph node metastasis, stage, and hematogeneous metastasis. Recurrent disease was found in 28 of 82 cases. Of 28 patients experiencing re－lapse, 15 patients were serially follow-up in every three months. The number positive of MMP-7 mRNA be－fore detection by imaging, at the same time of detection by imaging, and after detection by imaging was 5 cas－es, 8 cases and 2 cases respectively. Conclusion　Examination of MMP-7 mRNA in peripheral blood during follow-up is useful for early detection of occult recurrence.