Immunoglobulins in myasthenia gravis: effect of human lymph IgG 3 and F (ab')2 fragments on a cholinergic receptor preparation from Torpedo marmorata. |
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Authors: | A. K. LEFVERT,K. BERGSTR
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Affiliation: | A. K. LEFVERT,K. BERGSTRÖM |
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Abstract: | Lymph IgG from patients with myasthenia gravis was shown to inhibit the binding of radio-labelled Naja naja siamensis alpha-neurotoxin to membrane fragments from the electric organ of Torpedo marmorata. This effect could be related to IgG subclass 3 and to the F(ab')2 fragment. These findings confirm the involvement of antibodies of postsynaptic structures in myasthenia gravis. |
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Keywords: | Lymph proteins IgG IgG 3 F(ab)2 fragments myasthenia gravis cholinergic receptor |
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