|
|||||
|
|
| 一种实验性大鼠慢性阻塞性肺疾病模型的建立 | |
| 引用本文： | 金焱,庞宝森,武维屏,冯淬灵,任传云,牛淑洁,黄秀霞,崔巍,阮英茆. 一种实验性大鼠慢性阻塞性肺疾病模型的建立[J]. 心肺血管病杂志, 2004, 23(3): 179-181 |
| 作者姓名： | 金焱 庞宝森 武维屏 冯淬灵 任传云 牛淑洁 黄秀霞 崔巍 阮英茆 |
| 作者单位： | 1. 100029,北京中医药大学 2. 北京朝阳医院呼吸疾病研究所 3. 北京中医药大学附属东直门医院呼吸科 4. 北京中医药大学附属东直门医院中心实验室 5. 北京阜外医院病理科 |
| 基金项目： | 国家自然科学基金资助项目项目号 :3 0 2 0 0 3 66 |
| 摘 要： | 目的 :建立实验性大鼠慢性阻塞性肺疾病 (COPD)模型。方法 :采用香烟染毒和细菌内毒素 (LPS)气管注入的复合方法 ,模仿人类COPD发病的慢性过程 ,制造大鼠慢性阻塞性肺疾病模型。结果 :COPD模型肺组织平均肺泡面积较健康对照组明显增大 ,OD值明显减少 (P <0 0 1)。COPD模型组吸气阻力较健康对照组显著升高 ,肺顺应性 (CLd)及第 0 3s用力呼气量 (FEV0 3)与用力肺活量的比值(FEV0 3 FVC % )较健康对照组显著降低 ,表明有通气阻塞现象 (P <0 0 1)。结论 :本组大鼠COPD模型病理形态学改变和肺功能均与人类慢性阻塞性肺疾病的改变基本一致 |
| 关 键 词： | 慢性阻塞性肺疾病 动物模型,大鼠 |
| 修稿时间： | 2004-02-22 |
A kind of experimental method in establishing COPD rat model |
|
| JIN Yan,PANG Baosen,WU Weiping,FENG Cuiling,REN Chuanyun,NIU Shujie,HUANG Xiuxia,CUI Wei,RUAN Yingmao Beijing university of traditional chinese medicine,Beijing ,China. A kind of experimental method in establishing COPD rat model[J]. Journal of Cardiovascular and Pulmonary Diseases, 2004, 23(3): 179-181 | |
| Authors: | JIN Yan PANG Baosen WU Weiping FENG Cuiling REN Chuanyun NIU Shujie HUANG Xiuxia CUI Wei RUAN Yingmao Beijing university of traditional chinese medicine Beijing China |
| Affiliation: | JIN Yan,PANG Baosen,WU Weiping,FENG Cuiling,REN Chuanyun,NIU Shujie,HUANG Xiuxia,CUI Wei,RUAN Yingmao Beijing university of traditional chinese medicine,Beijing 100029,China |
| Abstract: | Objective:To establish an experimental COPD rat model.Method:By cigarette inhalation and intratracheal LPS Exposure, we established this COPD rat model.Result:alveolus areas per unit obviously increase in COPD group than normal group,the number of OD decrease significantly(P<0.01).Lung compliance and percentage of forced expiratory volume in first 0.3 second to forced vital capacity(FEV 0.3/FVC%)of COPD group are lower than normal group(P<0.01).Conclusion:The changes of pathology and lung function of this COPD rat model is as the same as the changes of COPD patients. |
| Keywords: | Chronic Obstructive Pulmonary Disease Animal model Rat |
| 本文献已被 CNKI 万方数据 等数据库收录！ | |