| 6种对乙酰氨基酚片的体外溶出度考察 |
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| 引用本文： | 梁智江,司徒冰.6种对乙酰氨基酚片的体外溶出度考察[J].中国临床药学杂志,1997,6(3):117-119. |
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| 作者姓名： | 梁智江 司徒冰 |
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| 作者单位： | 广州市第二人民医院 广州510150 |
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| 摘 要： | 采用紫外分光光度法对美国、香港及国内６个厂家生产的对乙酰氨基酚片进行体外溶出度测定，结果所检样品溶出度均符合中国药典１９９５版有关对乙酰氨基酚片的溶出规定，３０ｍｉｎ溶出超过８０％，６个品种的溶出度参数有非常显著差异（Ｐ〈０．０１），尤以幸福止痛素为优，这与制剂的工艺和辅料有关。
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| 关 键 词： | 对乙酰氨基酚片 溶出度 紫外分光光度法 |
DISSOLUTION OF SIX KINDS OF ACETAMINOPHEN TABLETS IN VITRO |
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| LIANG Zhi-Jiang SI Tu-Bing The Second Municipal People's Hospital of Guangzhou,Guangzhou.DISSOLUTION OF SIX KINDS OF ACETAMINOPHEN TABLETS IN VITRO[J].Chinese Journal of Clinical Pharmacy,1997,6(3):117-119. |
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| Authors: | LIANG Zhi-Jiang SI Tu-Bing The Second Municipal People's Hospital of Guangzhou Guangzhou |
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| Institution: | LIANG Zhi-Jiang SI Tu-Bing The Second Municipal People's Hospital of Guangzhou,Guangzhou 510150 |
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| Abstract: | The dissolution of six kinds of acetaminophen tablets manufactured by Ameri-ca, Hongkong and the domestic factories was determined with UV spectrophotometry in vit-ro. As a result, all the samples dissolved more than 80 percent of the labeled amount of C8H9NO2 in 30 minutes , which accorded with the demand of the Chinese Pharmacopoeia (Edition 1995). The parameters of them(T50,Td,T_(80),m)have very significant differences(P <0.01). Among them,the FORTOLIN has the fastest dissolution, which is relative to the excipient and the processing technique of the pharmaceutics. |
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| Keywords: | acetaminophen tablet dissoltion UV spectrophotometry |
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