小剂量红霉素治疗早产儿胃肠功能紊乱疗效观察

目的探讨小剂量红霉素治疗早产儿胃肠道功能紊乱的疗效。方法将符合诊断标准的69例患儿随机分为治疗组35例,对照组34例。治疗组在给予常规对症处理、支持治疗基础上加用小剂量红霉素3～5mg/(kg·d),缓慢静脉滴注,1次/d,连用7天。结果治疗组呕吐症状、胃肠潴留缓解及体重增长有效率分别为:77.1%、80.0%、74.3%。均高于对照组(P<0.05),具有明显的治疗作用。结论小剂量红霉素治疗早产儿胃肠道功能紊乱安全有效,具有一定的临床价值。

Study on Clinical Effect of Small Dose of Erythromycin for Preterm Infants with Gastrointentinal Dysfunction

Objective To study the clinical effect of a small dose of erythromycin for the preterm infants with gastrointentinal dysfunction. Methods 69cases of gastrointentinal dysfunction were divided into two groups at random. Erythromycin group of 35 cases and control group 34 cases. The control group was treated routinely. Besides routine therapy, Erythromcin groups were treated with intraveous erythromycin slowly dropping at a low dose of 3~5mg/(kg.d). Once a day and for 7 days.Results The effect rate of Erythromycin groups higher than that of control group(P <0.05), in signs of vomiting mitigating(77.1%),stomach retention (80.0%)and weight growing( 74.3%).No significant adverse effects were observed. Conclusion Low dose of erythromycin administration in the preterm infants with gastrointantinal dysfunction is effective in clinical practice.