慢性乙型肝炎患者血清GP73与肝纤维化的相关性

目的:探讨慢乙肝患者血清GP73与肝纤维化的相关性。方法:收集40例健康志愿者,110例慢乙肝患者进行血清GP73检测,同时病患组均进行HBeAg及肝功能等测定,并对结果进行统计。结果:1.肝纤维化各组较正常组均明显增高(P<0.01),随着纤维化的进展,肝纤维化分期组间也存在明显差别(P<0.01)。45例入院确诊为肝硬化的患者经扶正化瘀等治疗后,第7、30天复查GP73均较治疗前明显减低(P<0.05)且治疗后第30天与第7天相比也有明显差别(P<0.01)。2.所有肝硬化患者经child-pugh分级并与其GP73值进行相关分析,发现两者高度正相关(相关系数为r=0.922,P<0.01)。3.所有患者根据HBeAg阴、阳性进行分组,HBeAg(+)组GP73明显高于HBeAg(-)组(P<0.01)。结论:血清GP73的测定有助于肝纤维化病的诊断和肝损害情况的判断。

The relationship between liver fibrosis and GP73 in the patients with chronic hepatitis B

Objective:To investigate the relationship between liver fibrosis and GP73 in the patients with chronic hepatitis B.Methods: The serum levels of GP73 from 40 healthy contols and 110 patients with liver fibrosis were measured,and HBeAg,the liver function and other indicators were determined in the110 patients.Then the results were analyzed with statistical methods.Results: 1.The serum levels of GP73 were markedly higher in patients with liver fibrosis than those in healthy controls(P<0.01),and there was a significant difference among all the liver fibrosis groups(P<0.01).After Fuzheng Huayu and other drug therapy,the serum levels of GP73 in 45 patients with hepatic cirrhosis decreased significantly in the 7th day and the 30th day when compared to those before treatment(P<0.05),at the same time,the results of the 30th day were better than of the 7th day(P<0.01).2.After correlation study on child-pugh classification and serum levels of GP73,the correlation coefficient of child-pugh classification and GP73 was very high(r=0.922,P<0.01),It indicated child-pugh classification markedly positive correlated with serum levels of GP73.3.After all patients were divided into the HBeAg(+)group and HBeAg(-) group,the GP73 were found higher in the HBeAg(+)group than in the HBeAg(-) group.Conculsion: The serum levels of GP73 were helpful to diagnose liver fibrosis and estimate the severity of liver injury.