| 氟比洛芬酯用于高血压患者围术期镇痛对血浆内皮素浓度的影响 |
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| 引用本文： | 黄礼兵,季淑娟,崔苏扬. 氟比洛芬酯用于高血压患者围术期镇痛对血浆内皮素浓度的影响[J]. 安徽医药, 2009, 13(3): 311-313 |
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| 作者姓名： | 黄礼兵 季淑娟 崔苏扬 |
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| 作者单位： | 南京中医药大学附属医院麻醉科,江苏南京,210029;南京中医药大学附属医院麻醉科,江苏南京,210029;南京中医药大学附属医院麻醉科,江苏南京,210029 |
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| 摘 要： | 目的观察氟比洛芬酯复合吗啡用于高血压患者围术期镇痛对血浆内皮素（endothelin，ET）浓度的影响。方法择期行上腹部手术的高血压患者40例随机分为A组（单纯吗啡组）和B组（氟比洛芬酯复合吗啡组）。A组术毕行吗啡病人自控镇痛（PCA），B组于术前静脉注射氟比洛芬酯50mg，术后行氟比洛芬酯复合吗啡PCA。比较术后6、12、24、48h两组患者的VAS评分以及病人的总体舒适度，并于同时点采用放射免疫法测定血浆ET浓度。结果术后6、12、24hB组的VAS评分低于A组，各时点患者舒适度评分B组明显高于A组（P〈0．05）。术后6h两组患者的血浆ET浓度均有所升高，术后24、48hB组患者血浆ET值显著低于A组（P〈0．05）。结论围手术期创伤、应激可以引起血浆ET浓度升高；吗啡联合氟比洛芬酯能有效控制术后疼痛，减少高血压患者术后ET释放，有利于高血压患者的预后。
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| 关 键 词： | 内皮素 氟比洛芬酯 镇痛 吗啡 |
Effects of perioperative analgesia with flurbiprofen on plasma endothelia in patients with hypertension |
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| HUANG Li-bing,JI Shu-juan,CUI Su-yang. Effects of perioperative analgesia with flurbiprofen on plasma endothelia in patients with hypertension[J]. Anhui Medical and Pharmaceutical Journal, 2009, 13(3): 311-313 |
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| Authors: | HUANG Li-bing JI Shu-juan CUI Su-yang |
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| Affiliation: | HUANG Li-bing,JI Shu-juan,CUI Su-yang(Department of Anesthesiology,Jiangsu Provincial Hospital of TCM,Nanjing University of TCM,Nanjing 210029,China) |
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| Abstract: | Aim To study the effects of perioperative analgesia with flurbiprofen on plasma endothelia in patients with hypertension.Methods Forty patients with hypertention undergoing upper abdominal surgery were randomly assigned to two groups:morphine group(group A) and morphine combined with flurbiprofen group(group B).Group A received analgesia with morphine,while group B with flurbiprofen and morphine and flurbiprofen 50mg were given before surgery.VAS score at 6,12,24,48 h and BCS were recorded.Plasma endothelia... |
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| Keywords: | endothelia flurbiprofen analgesia morphine |
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