色素上皮衍生因子及其治疗视网膜新生血管性疾病的研究进展

视网膜新生血管（RNV）是目前最主要的致盲病因之一,迄今为止,尚无特效治愈方法。色素上皮衍生因子（PEDF）是新近发现的一种有效的眼内新生血管天然抑制剂,对新生血管的形成和发展起着重要的调控作用。有研究结果表明,应用PEDF重组蛋白或PEDF的眼内基因转移可以显著抑制RNV的形成,这为糖尿病性视网膜病变、早产儿视网膜病变及视网膜中央静脉阻塞等视网膜新生血管性疾病的治疗开辟了崭新的途径。因此,有必要就PEDF的生物学概况、对新生血管抑制作用的特点和机制及其在视网膜新生血管防治中的应用前景进行综述。（中华眼科杂志,2007,43：1043．1047）

Pigment epithelium-derived factor and its application in retinal angiogenic diseases

Retinal neovascularization (RNV) is one of the most important causes of blindness. No efficient treatment for RNV is available. Pigment epithelium-derived factor (PEDF) is a natural inhibitor of angiogenesis. It plays an important role in the modulation of ocular neovascularization. It has been demonstrated recently that the ischemia-induced retinal neovascularization can be dramatically inhibited by the recombinant PEDF protein or local viral vector-mediated delivery of PEDF cDNA, which predicts PEDF to be an optional strategy for intractable retinal angiogenic diseases like diabetic retinopathy, retinopathy of prematurity, and central retinal vein occlusion. Therefore, it is necessary to review the biological aspects of PEDF, its effect on the inhibition of angiogenesis and the prospect of using PEDF for the treatment of retinal neovascularization.