溴化异丙托品与氨茶碱片对支气管扩张作用的对比观察

目的比较定量雾化吸入溴化异丙托品与口服氨茶碱片对支气管扩张的作用。方法对２６例稳定期慢性阻塞性肺疾病（ＣＯＰＤ）患者采用安慰剂控制的双盲交叉试验，于试验前及试验后３０分，１，２，３，４，５，６小时分别测定第一秒用力呼气容积（ＦＥＶ１）。结果使用溴化异丙托品及氨茶碱后ＦＥＶ１平均峰值较基础值增加分别为３４％及１９％（Ｐ＜０．０１）；达峰时间分别为１～２小时及２～３小时；ＦＥＶ１较基础值增加＞１５％的患者分别为９０％及５０％（Ｐ＜０．０１）；ＦＥＶ１＞１５％的平均持续时间为３．６小时及１．６小时，６小时内ＦＥＶ１较基础值平均增加分别为１８％及８％（Ｐ＜０．０１）。结论对ＣＯＰＤ患者雾化吸入溴化异丙托品较口服氨茶碱片能更有效的扩张支气管作用

Comparing the bronchodilating effects of ipratropium bromide and theophylline

OBJECTIVE: To compare the bronchodilating effects of ipratropium bromide and theophylline in chronic obstructive pulmonary disease(COPD). METHOD: In 26 patients, mean peak forced expiratory volume in 1 second(FEV1) were measured at the time before and 30 minute, 1, 2, 3, 4, 5, 6 hours after the drugs were administered in a double-blind, placebo-controlled crossover method. RESULT: The mean peak of FEV1, increased over baseline were 34% and 19% respectively, for ipratropium bromide and theophylline (P < 0.01), and the reaching duration were 1-2 hours and 2-3 hours, the proportion of patients attaining at least a 15% (P < 0.01) increase in the FEV1, responders were 19% and 50% (P < 0.01) respectively, for ipratropium bromide and theophylline. The average FEV1, increased during the 6-hours observation period were 18% for ipratropium bromide and 8% for theophylline (P < 0.01). The mean duration of FEV1 > 15% was 3.6 and 1.6 hours respectively. CONCLUSION: Ipratropium bromide nebulized is a more potent bronchodilator than the oral theophylline in patients with chronic airflow obstruction.