Study on the efficacy and safety of Xueyou Mixture (血友合剂) in treating hemophilia |
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引用本文: | 刘陕西,江琳,刘义国,贺乐琴,梁鑫,孔伟伟,陈静.Study on the efficacy and safety of Xueyou Mixture (血友合剂) in treating hemophilia[J].Chinese Journal of Integrated Traditional and Western Medicine,2007,13(2):141-144. |
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作者姓名: | 刘陕西 江琳 刘义国 贺乐琴 梁鑫 孔伟伟 陈静 |
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作者单位: | Shanxi YiDa Institute of Hematopathy,Shanxi YiDa Institute of Hematopathy,Shanxi YiDa Institute of Hematopathy,Shanxi YiDa Institute of Hematopathy,Shanxi YiDa Institute of Hematopathy,Shanxi YiDa Institute of Hematopathy,Shanxi YiDa Institute of Hematopathy Xi' an 710061,Xi' an 710061,Xi' an 710061,Xi' an 710061,Xi' an 710061,Xi' an 710061,Xi' an 710061 |
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摘 要: | Objective:To observe the effect of Xueyou Mixture(血友合剂,XYM) on blood coagulation factors and its safety in treating hemophilia.Methods:To the randomly selected 65 inpatients of hemophilia,XYM was administered accompanied with intravenous dripping of liver cell growth factor 60-100 mg once a day to protect the liver,with no blood products like concentrated Ⅷ and FⅨ factors or blood plasma given.The treatment lasted for 3 weeks.The short-term eff icacy and adverse reactions were observed.The long-term efficacy in patients was observed in a follow-up study of 6-12 months after they were discharged from the hospital but continuously took XYM orally.Results:The short-term markedly effective rate in the patients was 95.38%(62/65).After they were treated for 3 weeks,the level of FⅧ factor activity increased in 56 patients of type A from(3.32±2.21) % to(4.18±2.23) %,and in 9 of type B from(4.92±1.81) % to(5.64±1.96) %.Compared with that before treatment,the difference was signif icant in both of them(P<0.01).No obvious adverse reaction was found in the treatment period.The follow-up study showed that in 22 patients of type A,the FⅧ factor activity ratio increased from(3.25±2.11) % to(6.31±2.16) %,(8.36±1.05) %,and(16.38±2.71) % in the 2nd,3rd and 6th month after discharge respectively,all showing significant difference to that before treatment(P<0.01);and in 4 patients of type B,it increased from(4.15±2.26) % to 7.8% and 11.6%(mean value) in the 2nd and 6th month respectively.Conclusion:XYM could raise the activity of factors Ⅷ and Ⅸ in patients with hemophilia,and the degree of the rise is related with the duration of the therapy,with no obvious adverse reaction,which strikes out a new path and new train of thinking for the treatment of the disease by non-blood preparation.
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关 键 词: | 血友合剂 血友病 安全性 有效性 |
收稿时间: | 22 December 2006 |
修稿时间: | 2006-12-22 |
Study on the efficacy and safety of Xueyou Mixture in treating hemophilia |
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Authors: | Prof Shan-xi Liu Lin Jiang Yi-guo Liu Yue-qin He Xin Liang Wei-wei Kong and Jing Chen |
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Abstract: | Objective To observe the effect of Xueyou Mixture (血友合剂, XYM) on blood coagulation factors and its safety in treating hemophilia.
Methods To the randomly selected 65 inpatients of hemophilia, XYM was administered accompanied with intravenous dripping of liver
cell growth factor 60–100 mg once a day to protect the liver, with no blood products like concentrated VIII and FIX factors
or blood plasma given. The treatment lasted for 3 weeks. The short-term efficacy and adverse reactions were observed. The
long-term efficacy in patients was observed in a follow-up study of 6–12 months after they were discharged from the hospital
but continuously took XYM orally.
Results The short-term markedly effective rate in the patients was 95.38% (62/65). After they were treated for 3 weeks, the level
of FVIII factor activity increased in 56 patients of type A from (3.32±2.21) % to (4.18±2.23) %, and in 9 of type B from (4.92±1.81)
% to (5.64±1.96) %. Compared with that before treatment, the difference was signifi cant in both of them (P<0.01). No obvious adverse reaction was found in the treatment period. The follow-up study showed that in 22 patients of type
A, the FVIII factor activity ratio increased from (3.25±2.11) % to (6.31±2.16) %, (8.36±1.05) %, and (16.38±2.71) % in the
2nd, 3rd and 6th month after discharge respectively, all showing significant difference to that before treatment (P<0.01); and in 4 patients of type B, it increased from (4.15±2.26) % to 7.8% and 11.6% (mean value) in the 2nd and 6th month
respectively.
Conclusion XYM could raise the activity of factors VIII and IX in patients with hemophilia, and the degree of the rise is related with
the duration of the therapy, with no obvious adverse reaction, which strikes out a new path and new train of thinking for
the treatment of the disease by nonblood preparation. |
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Keywords: | Xueyou Mixture hemophilia therapeutic eff icacy |
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