Expressions of VEGF and Ki-67 in eutopic endometrium of patients with endometriosis and effect of Quyu Jiedu Recipe (祛瘀解毒方) on VEGF expression |
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引用本文: | 连方,刘海萍,王云霞,张建伟,孙振高,马凤梅,张宁,刘延荷,孟茜.Expressions of VEGF and Ki-67 in eutopic endometrium of patients with endometriosis and effect of Quyu Jiedu Recipe (祛瘀解毒方) on VEGF expression[J].Chinese Journal of Integrated Traditional and Western Medicine,2007,13(2):109-114. |
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作者姓名: | 连方 刘海萍 王云霞 张建伟 孙振高 马凤梅 张宁 刘延荷 孟茜 |
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作者单位: | Reproduction Center Affiliated Hospital of Shandong University of TCM,Shandong University of TCM,Shandong Provincial Academy of Medical Sciences,Shandong University of TCM,Reproduction Center Affiliated Hospital of Shandong University of TCM,Reproduction Center Affiliated Hospital of Shandong University of TCM,Shandong University of TCM,Reproduction Center Affiliated Hospital of Shandong University of TCM,Reproduction Center Affiliated Hospital of Shandong University of TCM,Jinan 250011,Jinan 250011,Jinan 250011,Jinan 250011,Jinan 250011 |
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基金项目: | 山东省医药卫生科研项目 |
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摘 要: | Objective:To observe the clinical eff icacy of Quyu Jiedu Recipe(祛瘀解毒方,QJR) in treating endometriosis(EM),and to explore the levels of vascular endothelial growth factor(VEGF) and cell proliferative nucleoprotein antigen(Ki-67),their changes before and after treatment and the clinica signifi cance in the trial.Methods:Fifty patients of EM were randomly assigned to two groups.The 26 patients in the QJR group were treated with QJR,and the 24 patients in the gestrinone(GT) group with gestrinone.Besides,a normal control group with 20 healthy women was set up.The therapeutic effects in the two treated groups were compared.Expressions of VEGF and Ki-67 in eutopic endometrium of all subjects(with both patients and healthy women at the median secretive phase) were determined with immunohistochemical stain before treatment,and the determination in the two treated groups was repeated after 3-month treatment in the same phase.Results:Before treatment,the VEGF and Ki-67 expression positive rates and their mean optic density(MOD) were higher in patients than in healthy women(P<0.05).After treatment,the positive rate and MOD of VEGF expression lowered signif icantly than before treatment(P<0.05),but those of Ki-67 changed insignifi cantly,and comparison between the two treated groups showed no significant difference(P>0.05).Conclusion:QJR could markedly improve the symptoms of menorrhagia and menstrual disorder,and its mechanism might be related with the lowering of eutopic endometrial VEGF expression.VEGF and Ki-67 show a high expression in eutopic endometrium of patients with EM.
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关 键 词: | 子宫内膜异位症 处方 毒素 血管生长 Ki-67 |
收稿时间: | 27 October 2006 |
修稿时间: | 2006-10-27 |
Expressions of VEGF and Ki-67 in eutopic endometrium of patients with endometriosis and effect of Quyu Jiedu Recipe on VEGF expression |
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Authors: | Prof Fang Lian Hai-ping Liu Yun-xia Wang Jian-wei Zhang Zhen-gao Sun Feng-mei M Ning Zhang Yan-he Liu and Qian Meng |
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Abstract: | Objective To observe the clinical efficacy of Quyu Jiedu Recipe (祛瘀解毒方, QJR) in treating endometriosis (EM), and to explore the levels
of vascular endothelial growth factor (VEGF) and cell proliferative nucleoprotein antigen (Ki-67), their changes before and
after treatment and the clinical significance in the trial.
Methods Fifty patients of EM were randomly assigned to two groups. The 26 patients in the QJR group were treated with QJR, and the
24 patients in the gestrinone (GT) group with gestrinone. Besides, a normal control group with 20 healthy women was set up.
The therapeutic effects in the two treated groups were compared. Expressions of VEGF and Ki-67 in eutopic endometrium of all
subjects (with both patients and healthy women at the median secretive phase) were determined with immunohistochemical stain
before treatment, and the determination in the two treated groups was repeated after 3-month treatment in the same phase.
Results Before treatment, the VEGF and Ki-67 expression positive rates and their mean optic density (MOD) were higher in patients
than in healthy women (P<0.05). After treatment, the positive rate and MOD of VEGF expression lowered significantly than before treatment (P<0.05), but those of Ki-67 changed insignificantly, and comparison between the two treated groups showed no significant difference
(P>0.05).
Conclusion QJR could markedly improve the symptoms of menorrhagia and menstrual disorder, and its mechanism might be related with the
lowering of eutopic endometrial VEGF expression. VEGF and Ki-67 show a high expression in eutopic endometrium of patients
with EM.
Supported by Research Projects of Medical Science and Hygiene of Shandong Province 1999 (No. 42) |
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Keywords: | endometriosis Quyu Jiedu Recipe stagnancy of toxin vascular endothelial growth factor Ki-67 |
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