Endocrine Changes of the Hypothalamic, Pituitary and Adrenal Systems in Cyclic Vomiting |
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| Authors: | Sekoiya Aritaki M.D. Masaaki Ogihara M.D. Isao Kusakawa M.D. Hikari Takamiya M.D. Yoshihiro Hori M.D. Naoshi Kawashima M.D. Tasuku Miyajima M.D. Tomoyuki Chiba M.D. Kazumitsu Tsuyuki M.D. Koji Takekuma M.D. Tetsuhiko Matsuno M.D. Teruo Honda M.D. |
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| Affiliation: | Department of Pediatrics, Tokyo Medical College, Tokyo |
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| Abstract: | Children with cyclic vomiting had high blood ADH, ACTH, cortisol and plasma renin activity (PRA) during vomiting, and urinary excretion of 170HCS, 17KGS, 17KS, norepinephrine (NE), epinephrine (E), normetanephrine (NMN), metanephrine (MN) and vanillylmandelic acid (VMA) was increased. After disappearance of the vomiting, the levels fell to within the normal range. Variation was not observed in blood prolactin (PRL), Na, osmotic pressure or urine dopamine (DA). Normal findings were obtained in the intravenous water loading test, response of anterior pituitary hormones and cortisol to the insulin, TRH and LH-RH loading, the metopirone test and the dexamethasone suppression test which were performed 1 week after the vomiting. |
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| Keywords: | Cyclic vomiting, ADH, ACTH, Cortisol, Catecholamine. |
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