Myeloperoxidase, but not oxidized LDL, is associated with leisure-time physical activity: results from the MONICA/KORA Augsburg Studies 1984-1995 |
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| Authors: | Autenrieth Christine S Emeny Rebecca T Herder Christian Döring Angela Peters Annette Koenig Wolfgang Thorand Barbara |
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| Affiliation: | aInstitute of Epidemiology II, Helmholtz Zentrum München, German Research Center for Environmental Health, Neuherberg, Germany;bInstitute for Clinical Diabetology, German Diabetes Center, Leibniz Center for Diabetes Research at Heinrich Heine University Düsseldorf, Düsseldorf, Germany;cDepartment of Internal Medicine II-Cardiology, University of Ulm Medical Center, Ulm, Germany |
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| Abstract: | ObjectiveOxidative stress-induced cell damage contributes to several chronic conditions such as cardiovascular disease, but only very few population-based studies have examined the influence of regular physical activity (PA) on oxidative stress.Methods1820 men and women aged 35–74 years were randomly drawn from three population-based MONICA/KORA Augsburg Studies conducted between 1984 and 1995. Geometric means of the oxidative stress markers myeloperoxidase (MPO) and oxidized LDL (ox-LDL) were calculated and multiple linear regression was performed to assess their associations with three self-reported PA domains, namely work, leisure-time or walking.ResultsMean MPO concentrations were lower for participants engaged in high leisure-time PA (124.2 μg/ml; 95%-CI, 116.8–132.0) compared to the inactive reference group (133.5 μg/ml; 95%-CI, 127.6–139.6) (Ptrend across PA levels: 0.007). No significant association between ox-LDL and PA domains was observed (Ptrend between 0.162 and 0.803).ConclusionThese data indicate that regular leisure-time PA may reduce MPO concentrations. |
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| Keywords: | Oxidative stress MPO ox-LDL Domains of physical activity Atherosclerosis Population-based study |
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