Plasma atrial natriuretic peptide and the renin-aldosterone system during long-term administration of the diuretic xipamide in man |
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| Authors: | Lijnen P. Hespel P. Fagard R. Staessen J. Goossens W. Lissens W. Amery A. |
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| Affiliation: | (1) Hypertension and Cardiovascular Rehabilitation Unit, University of Leuven, Belgium;(2) Laboratory of Hematology, University of Leuven, Belgium;(3) Central Laboratory, University Hospital Gasthuisberg, University of Leuven, Belgium |
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| Abstract: | Summary We have studied the effect of xipamide on plasma α-atrial natriuretic peptide and the reninaldosterone-kallikrein system in twelve healthy men, using a double-blind cross-over design. After a run-in period on placebo for 1 week the subjects were treated with either placebo (n=6) or xipamide 20 mg once daily (n=6) for 16 weeks and were then switched to the alternative medication for another 16 weeks. The plasma concentration of α-atrial natriuretic peptide fell after 1 week of xipamide administration and increased during prolonged xipamide administration but remained suppressed. The changes in plasma α-ANP observed after 1 week of xipamide were negatively correlated with the changes in haematocrit and haemoglobin. Plasma renin activity (PRA), aldosterone concentration (PAC), and urinary excretion of aldosterone and kallikrein increased after 1 week of xipamide administration, levelled off during the second and fourth weeks, but remained elevated during further prolonged xipamide administration for 16 weeks. The xipamide-induced changes in PRA and PAC were positively correlated with the changes in the haematocrit and haemoglobin. Our data suggest that the changes in plasma renin, aldosterone, and α-atrial natriuretic peptide during xipamide administration may be related to diuretic-induced volume contraction. |
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| Keywords: | alpha-atrial natriuretic peptide xipamide plasma renin activity plasma aldosterone urinary kallikrein excretion healthy volunteers |
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