| 兔动脉粥样硬化时红细胞及血清唾液酸含量的改变 |
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| 引用本文： | 王京 史荫绵. 兔动脉粥样硬化时红细胞及血清唾液酸含量的改变[J]. 第二军医大学学报, 1994, 15(3): 236-240 |
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| 作者姓名： | 王京 史荫绵 |
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| 作者单位： | 第二军医大学长海医院神经内科，北京市海军总医院干一科 |
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| 摘 要： | 用食饵性高血脂及食饵性高血脂加免疫性动脉内皮损伤的方法建立兔动脉粥样硬化模型，观察到随着动脉粥样硬化病的发生，红细胞膜唾液酸含量降低而血清唾液酸含量增高，对与照组比较均有显著性差异（Ｐ＜０．０５）。动脉继样硬化的程度与红细胞膜唾液酸含量呈显著负相关（Ｐ＜０．０１），与血清唾液酸含量呈显著正相关（Ｐ＜０．０５）。实验结果提示：红细胞膜和血清唾液酸含量的变化与动脉粥样硬化病变的形成及病损程度可能有密切
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| 关 键 词： | 唾液酸 红细胞 血清 动脉粥样硬化 |
The Observation on the Contents of Sialic Acid of Erythrocyte Membrane and Serum in the Rabbits with Atherosclerosis |
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| Wang Jing,Shi Yinmian,Zheng Huimin. The Observation on the Contents of Sialic Acid of Erythrocyte Membrane and Serum in the Rabbits with Atherosclerosis[J]. Former Academic Journal of Second Military Medical University, 1994, 15(3): 236-240 |
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| Authors: | Wang Jing Shi Yinmian Zheng Huimin |
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| Abstract: | The model of experimental atherosclerosis was established in rabbits by means of cholesterol-fed and cholesterol-fed combined with immunopathologic endothelial injudes,respectively.When atherosclerosis occurred the content of sialic acid(SA) on the erythrocyte membrane decreased,but that in serum increased and both of the changes had significant difference as compared with the control(P<0.05).The content of SA on erythrocyte membrane expressed significant negative correlation(P<0.01) but that of SA in serum expressed significant positive correlation(P<0.05) with the degree of atheroselerotic lesions.These results show that there is a close relationship between the contents of SA on erythrocytes and in serum and the atherosclerotic occurence and degree of the lesion. |
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| Keywords: | sialic acid erythrocytes serum atheroslerosis rabbits |
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