全身炎症反应综合征的分子发病机制及其治疗研究

全身炎症反应综合征(SIRS)是机体对感染性或非感染性因素产生的反应,是严重感染、败血症和休克发展到多器官功能不全(MODS)的共同通路。在其发生发展过程中,存在着多种调节因子的相互作用以及促炎反应和抗炎反应的平衡和失衡,深入研究其分子机制,将为SIRS的临床治疗提供新的途径。此文综述了SIRS的病理生理过程及分子发病机制,涉及到炎症细胞激活、细胞因子产生及其主要的信号转导通路等,在此基础上,扼要介绍了生物反应调节治疗方面的一些研究进展。

Progress about molecular mechanism and treatment of systemic inflammatory response syndrome

The systemic inflammatory response syndrome(SIRS) is the body's response to an infectious or noninfectious insult.It is the common way from severe infection,sepsis,septic shock to multi-organ dysfuction syndrome(MODS).Although the mechanisms are not yet completely explored,extensive science research has been investigated widely on inflammatory signal molecules involving in the initiation of SIRS and information of the disease.It has provided the basis for a new developmental area for novel therapeutic strat...