老年高血压患者胰岛素抵抗的特征

目的 探讨老年高血压患者胰岛素抵抗的特征.方法 选择高血压病患者60例(老年,非老年各30例),以及与高血压组体重指数有可比性的正常血压者20例,测定其血清总胆固醇(TC),甘油三酯(TG),空腹血糖(FBG),餐后2h血糖(PBG),淋巴细胞内Ca2+的浓度,计算胰岛素敏感指数(ISI),三组逐项进行对照.结果 (1)高血压组与正常血压组对照,存在高胰岛素血症,胰岛素抵抗和多种代谢紊乱;(2)老年高血压组与非老年高血压组比较,前者TG、FBG、PBG、FINS、PINS水平和Ca2+浓度显著增高,胰岛素敏感指数显著降低.结论 老年高血压有更加明显的高胰岛素血症,更严重的胰岛素抵抗和多种代谢紊乱,这可能与增龄、老化有关.

The Features of Insulin Resistance on Elderly Hypertensive Patients

Objective To investingate the features of insulim resistance in elderly hypertensive patients. Methods The levels of serum toatal eholesterol(TC),serum triglycedde(TG),fasfing blood glnsose(FBG),2h postprandial blood glucose(PBG),fasting insulin (FINS),2h postprandial insulim (PINS),intracellular free calcium of lymphocyte ([Ca2+i) were respecfived measured,then the insulin sensitivity index (ISI) wad calculated,and compared in 60 essential hypertensive patients (30 elderly,30 non-elderly) and 20 weight index matched normotensive control subjects. Results (1)the hypertensive patients compared with normotensive control subjects,the patients had hyperinsumlinemia,insulin resistance and multiple metabolic disorders. (2)The elderly hypertensive patients compared with the non-elderly hypertensive patients,the levels of TG,FBG,PBG,FINS,PINS and [Ca2+]i were Significantly higher but ISI was significantly lower,in the elderly hypertensive patients. Conclusion The elderly hypertensive patients had more obvious hyperonsulinemia,severe insulin resistance and multiple metaboie disorders,these maybe related to aging and degeneracy.