脉络膜上腔给药治疗兔眼穿通伤

目的 比较脉络膜上腔给药与全身给药治疗眼穿通伤的疗效。方法 16只日本大耳白兔制成双眼穿通伤模型,分为 经脉络膜上腔给药与全身给药两组,经处理后行视网膜脱离及玻璃体浑浊评级、眼底造影及组织病理研究。结果 脉络膜上 腔给药组抑制炎症和增殖反应的效果优于全身给药组。结论 脉络膜上腔给药安全有效,可作为一种新的穿通伤治疗手段。

Effect of suprachoroidal space drug administration in perforating ocular injury in rabbits

Aim To compare the therapeutic effects of suprachoroidal space drug administration and muscle injection on perforating ocular injury. Methods Sixteen normal rabbits were divided into two groups: A and B. After induction of perforating ocular injury, tri-amcinolone acetonide, 1mg, was administered into suprachoroidal space in Group A and dexamison, 3mg, was given by muscular injection for 3 days in Group B. The effect was measured by the grade of retinal detachment, vitreous body opacification, FFA and histopathology. Results The effect of suprachoroidal space administration was superior to that of muscle injection. Conclusion The suprachoroidal space drug administration is safe and effective and provides a new choice for treating perforating ocular injury.