| 非诺贝特对2型糖尿病大鼠肾皮质纤溶酶原激活物抑制物1表达的影响 |
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| 引用本文： | 张皎月,陈璐璐,王保平,王咏波,张亚萍.非诺贝特对2型糖尿病大鼠肾皮质纤溶酶原激活物抑制物1表达的影响[J].中华糖尿病杂志,2005,13(5):343-345. |
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| 作者姓名： | 张皎月 陈璐璐 王保平 王咏波 张亚萍 |
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| 作者单位： | 华中科技大学同济医学院附属协和医院内分泌科,武汉430022 |
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| 摘 要： | 小剂量链脲佐菌素加高脂饮食诱导的糖尿病大鼠给予非诺贝特灌胃8周，检测显示糖尿病大鼠肾皮质纤溶酶原激活物抑制物1（PAI-1）mRNA表达明显下降，同时肾小球肥大部分改善，提示非诺贝特对糖尿病肾脏的保护作用可能与其下调肾皮质PAI-1基因表达有关。
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| 关 键 词： | 过氧化物酶体增殖物激活受体 非诺贝特 糖尿病肾病 纤溶酶原激活物抑制剂1 大鼠 |
| 收稿时间： | 2004-05-24 |
| 修稿时间： | 2004年5月24日 |
Effect of PPARα activator fenofibrate on PAI-1 expression in renal cortex of type 2 diabetic rats |
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| ZHANG Jiao-yue , CHEN Lu-lu, WANG Bao-ping ,et al..Effect of PPARα activator fenofibrate on PAI-1 expression in renal cortex of type 2 diabetic rats[J].CHINESE JOURNAL OF DIABETES MELLITUS,2005,13(5):343-345. |
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| Authors: | ZHANG Jiao-yue CHEN Lu-lu WANG Bao-ping |
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| Institution: | ZHANG Jiao-yue , CHEN Lu-lu, WANG Bao-ping , et al. |
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| Abstract: | Diabetic rat model which was induced by low dose of streptozotocin and high fat diet was administrated with fenofibrate for 8 weeks. It showed that PAI-1 mRNA level in renal cortex of diabetic rats was significantly decreased after the treatment, so was the glomerular hypertrophy, which demonstrated that the protective effect of fenofibrate against diabetic nephropathy was, at least in part, related to the decrease of PAI-1 gene expression in renal cortex. |
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| Keywords: | Peroxisome proliferator activated receptor Fenofibrate Diabetic nephropathy Plasminogen activator inhibitor-1 Rat |
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