雾化吸入液酸碱度对COPD患者痰液特性的影响梯度

目的通过对雾化吸入液酸碱度的调节,观察不同PH值的雾化溶液对慢性阻塞性肺疾病(COPD)患者痰液理化性质的影响。方法12例COPD住院患者,分别给予PH 6.4、7.4、8.4、9.4的等渗雾化溶液行雾化吸入,雾化前、后1小时收集病人普液检测诱导痰液量、干/湿重及黏度。结果PH 6.4和PH 7.4的雾化溶液对痰液特性无明显影响,PH 8.4的雾化溶液可明显增加排痰量、降低痰液干/湿重及黏度,痰液特性得到改善。PH 9.4时患者主观上已难以接受。结论雾化液PH值对痰液特性有明显影响,适度偏碱的雾化溶液更有利于痰液流变性质的改善。

Effects of the liquid with different PH inhalation on the sputum of patients with chronic obstructive pulmonary disease

Objective To observe the influence of physical and chemical properties of COPD patients' phlegm by the use of inhalation liquid with different PH values and in modulating acidity and alkalinity of the liquid inhaling.Methods Tweleve COPD inpatients inhaled isotonic inhalation liquid with the PH values of,respectively in sequence,6.4,7.4,8.4,9.4.The patients' sputum 1 hour before and after inhalation were collected and the revulsive sputum volume,the dry/wet weight ratio and the mucosity were tested.Results There was no obvious influence on the phlegm property by the liquid with the PH values of 6.4 and 7.4.The liquid with the PH values of 8.4 increased the sputum volume,decreased the dry/wet weight ratio and the mucosity.The phlegm property had been improved.The patients had difficult to accept the liquid with PH 9.4.Conclusion The PH value of the liquid can influence phlegm property.The liquid with a little bit alkalescent is most likely to improve the characteristics of phlegm.