Prodigiosin induces apoptosis of B and T cells from B-cell chronic lymphocytic leukemia. |
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| Authors: | C Campàs M Dalmau B Montaner M Barragán B Bellosillo D Colomer G Pons R Pérez-Tomás J Gil |
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| Affiliation: | Department de Ciències Fisiològiques II, Unitat de Bioquímica, Facultat de Medicine, Universtitat de barcelona, Spain. |
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| Abstract: | We have previously reported that prodigiosin (2-methyl-3-pentyl-6-methoxyprodigiosene) induces apoptosis in human hematopoietic cancer cell lines with no marked toxicity in nonmalignant cell lines. In this study, we demonstrate that prodigiosin induces apoptosis of B-cell chronic lymphocytic leukemia (B-CLL) cells (n=32 patients). The dose-response for the cytotoxic effect of prodigiosin was analyzed in cells from 12 patients showing an IC(50) of 116+/-25 nM. Prodigiosin induced apoptosis of B-CLL cells through caspase activation. We also analyzed the cytotoxic effect of prodigiosin in T cells from B-CLL samples and no differences were observed with respect to leukemia cells. This is the first report showing that prodigiosin induces apoptosis in human primary cancer cells. |
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