| 碘量法测定药物含量的不确定度 |
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| 引用本文： | 季宁,李秀明. 碘量法测定药物含量的不确定度[J]. 安徽医药, 2006, 10(9): 672-673 |
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| 作者姓名： | 季宁 李秀明 |
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| 作者单位： | 安徽省滁州市药品检验所,安徽,滁州,239000;安徽省滁州市药品检验所,安徽,滁州,239000 |
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| 摘 要： | 目的通过碘液滴定维生素C片含量分析的不确定度评价,建立普遍适用于碘量法测定药物含量的不确定度评定方法。方法分析标准溶液标定中引入的标准溶液浓度的不确定度,供试品测定时的各种影响因素并对各个不确定度分量进行评估。结果建立了碘量法测定药物含量的数学模型,推导出不确定度的计算公式并计算各分量的不确定度,最后计算出合成不确定度。结论建立的不确定度计算方法适用于碘量法定量测定药物含量的不确定度的评价。
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| 关 键 词： | 不确定度 碘量法 含量测定 |
| 收稿时间： | 2006-03-15 |
| 修稿时间： | 2006-03-15 |
Evaluation of the uncertainty of iodomotry in pharmaceutical analysis |
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| JI Nin,LI Xiu-ming. Evaluation of the uncertainty of iodomotry in pharmaceutical analysis[J]. Anhui Medical and Pharmaceutical Journal, 2006, 10(9): 672-673 |
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| Authors: | JI Nin LI Xiu-ming |
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| Affiliation: | Chuzhou Institute for Drug Control, Chuzhou 239000 |
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| Abstract: | Aim To establish a method for uncertainty evaluation in iodomotry with Vitamine C.Methods The concentration uncertainty from the preparation of standard solutions and the factors affecting sample detection were analyzed.Each component of uncertainty was calculated by analyzing the various variable parameters in the procedure.Results The calculation formula of uncertainty was deduced from the procedure of titration.The combined uncertainties were then finally obtained by synthesizing the uncertainties of various component variables.Conclusion This mathematic model of uncertainty estimation is reasonable and reliable. |
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| Keywords: | pharmaceutical analysis iodomotry ncertainty |
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