| 金雀异黄素的抗雌激素效应 |
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| 引用本文： | 余增丽,张立实,吴德生.金雀异黄素的抗雌激素效应[J].卫生研究,2003,32(2):125-127. |
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| 作者姓名： | 余增丽 张立实 吴德生 |
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| 作者单位： | 四川大学华西公共卫生学院,成都,610041 |
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| 基金项目： | 国家自然科学基金重点项目 (No .30 0 30 1 2 0 ) |
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| 摘 要： | 应用雌激素耗尽的方法诱导乳腺癌细胞株MCF - 7和T47D发生凋亡 ,从而探讨金雀异黄素(genistein ,GS)对凋亡的影响作用。结果表明 ,同抗雌激素药物它莫西芬类似 ,3 2× 10 - 6 mol L及 96× 10 - 6 mol LGS可加剧雌激素耗尽所诱导的细胞凋亡作用 ,且这种效应存在着良好的剂量 -效应关系。结果提示GS对女性乳腺癌发病率的预防作用是通过其抗雌激素效应诱导细胞的凋亡而实现的
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| 关 键 词： | 金雀异黄素 乳腺癌细胞株MCF-7 乳腺癌细胞株T47D 细胞凋亡 |
| 文章编号： | 1000-8020(2003)02-0125-03 |
| 修稿时间： | 2002年7月4日 |
Genistein induced apoptosis in MCF-7 and T47D cells |
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| Yu Zengli,Zhang Lishi,Wu Desheng Huaxi School of Public Health,Sichuan University,Chengdu ,China.Genistein induced apoptosis in MCF-7 and T47D cells[J].Journal of Hygiene Research,2003,32(2):125-127. |
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| Authors: | Yu Zengli Zhang Lishi Wu Desheng Huaxi School of Public Health Sichuan University Chengdu China |
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| Institution: | Huaxi School of Public Health, Sichuan University, Chengdu 610041, China. |
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| Abstract: | Dietary genistein, a natural flavone compound found in soy, has been proposed to be related to the lower prevalence of breast cancer in Asian women. In order to elucidate the mechanism of chemopreventive effect of genistein so that to provide more scientific basis for dietary intervention for breast cancer in women, the apoptosis in estrogen responsive breast cancer cell lines (MCF-7 and T47D cells) was induced as the study model and the effect of genistein on the apoptosis was observed. The results showed that, functionally similar to the anti-estrogen tamoxifen, genistein induced in a dose- and time-dependent manner the MCF-7 cell apoptosis at concentrations above 20 x 10(-6) mol/L. The findings suggested that the increased isoflavone intake can induce apoptosis in estrogen responsive cells. |
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| Keywords: | genistein breast cancer MCF 7 breast cancer T47D apoptosis |
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