|
|||||
|
|
Sulfur in human crystallins |
|
| Authors: | Srikanthan Durga Bateman Orval A Purkiss Andrew G Slingsby Christine |
| Affiliation: | Department of Crystallography, Birkbeck College, University of London, Malet Street, London WC1E 7HX, UK. |
| Abstract: | Molecular models of human gamma-crystallins and the 'alpha-crystallin domain' of human alphaA-crystallin have been built based on available related X-ray crystal structures. The accessibilities of the component cysteine, methionine and tryptophan side chains in the crystallin models have been calculated. The reactivities of these cysteines, which are oxidised in cataract, are assessed based on their known modifications and within the context of their location within the 3D models. |
| Keywords: | αA-crystallin cataract cysteine lens βB1-crystallin γ-crystallins glutathione homology models oxidation sulfinic acid solvent accessibility |
| 本文献已被 ScienceDirect PubMed 等数据库收录！ | |