核素肾动态显像对急性上尿路梗阻肾功能修复的实验研究

目的:探讨放射性核素肾动态显像与上尿路梗阻后肾功能恢复的相关性。方法:我们建立了狗和大白兔的上尿路梗阻动物模型,并应用放射性核素显像、光镜技术观察和检测梗阻不同时期肾脏的功能和病理改变及梗阻解除后的肾功能恢复情况。结果:梗阻8～10d的实验动物,解除梗阻2周后,肾功能基本恢复。梗阻4～6周的实验动物,解除梗阻4月后,肾功能可恢复到轻-中度损伤程度。梗阻7～8周的实验动物,解除梗阻4月后,肾功能无法恢复。结论:放射性核素显像是评价肾功能修复的重要技术手段,可作为外科判断梗阻后肾切除与否的可靠指标。

The experimental observation on the recovery of renal function in animals with upper urinary tract observation using dynamic renal imaging

Objective:To evaluate the relationship between the renal dynamic radionuclide imaging and the changes of recovery of renal function with upper urinary tract obstruction.Methods:We built up animal model of upper urinary tract obstruction in dogs and NZ hares.Using the technique of radionuclide imaging and microscope,we observed and detected the function and pathology changes of kidneys during the period of obstruction and their function recovery after relief following surgical treatment.Results:In animals with a durations of 8~10 days' obstruction,renal functions could totally be recovered two weeks later after relief of obstructions with surgical interventions,and also,in animals with 4 to 6 weeks' obstruction,renal functions could also be recovered to some extent within 4 months after relief of obstructions.By contrast,in animals with 7 ~8 weeks' obstruction,renal functions could not be recovered within 4 months after relief of obstructions.Conclusion:The result indicated that renal dynamic radionuclide imaging might be an important method for evaluating the changes of recovery of renal function,and could be used as an reliable indicator in the determination of renal ectomy or not for surgeons after a certain time of obstruction.