中国汉族正常成人颞叶体积的高分辨率MRI测量

目的 研究中国汉族正常成人颞叶MRI形态特征,为建立中国标准脑提供颞叶形态学测量数据.方法 采用全国多中心临床研究形式,选取18～70岁健康志愿者300名,按照年龄18～30、31～40、41～50、51～60、61～70岁进行分组,分别定义为A、B、C、D、E组,每组男、女各30名.所有受试者均行3D磁化强度预备梯度回波序列T1WI采集颞叶体积,并对不同性别和年龄段标准化后的左、右侧颞叶体积分别进行方差分析.结果 男性左、右侧颞叶体积分别为(97 126±15 703)、(97 015±15 545)mm3,女性左、右侧颞叶体积分别为(95 123±14 564)、(96 423±13 407)mm3,左、右侧颞叶体积在性别上差异无统计学意义(F值分别为1.336、0.127,P值分别为0.249、0.722).5组左侧颞叶体积分别为(93 873±13 351)、(95 566±11 964)、(101 890±14 511)、(93 972±14 050)、(95 636±19 864)mm3,右侧颞叶体积分别为(93 409±10 984)、(98 158±16 392)、(102 079±15 112)、(95 448±11 123)、(94 658±16 928)mm3,5组间左、右侧颞叶体积差异有统计学意义(F值分别为2.940、3.514,P值分别为0.021、0.008).进一步两两间比较,C组左、右侧颞叶体积高于A、D组(p值均<0.05),其余各组间差异无统计学意义(P值均>0.05).结论 高分辨率MRI能提供较为精确的颞叶图像和测量数据,为建立中国标准脑提供了科学数据.

Measuring the volume of temporal lobe in healthy Chinese adults of the Hart nationality on the high-resolution MRI

Objective To explore the morphological features of temporal lobe of healthy Chinese Han adults on the high-resolution MRI and provide morphological data of temporal lobe for the construction of database for Chinese Standard Brain.Methods This is a clinical multi-center study.Three hundred healthy Chinese volunteers (male 150, and female 150) recruited from 15 hospitals were divided equally into five groups according to their age, i.e., 18-30 ( Group A ), 31-40 ( Group B ), 41-50 ( Group C ), 51-60(Group D), 61-70( Group E).All subjects were scanned using T1WI 3D MPRAGE sequence and volumes of standardized temporal lobe were collected.The bilateral volumes of standardized temporal lobe were compared by variance analysis between male and female subjects and among five age groups.Results The mean volumes of left and right temporal lobe were (97 126±15 703) mm3 and (97 015±15 545) mm3 respectively for men, and (95 123±14 564) mm3 and (96 423±13 407) mm3 for women.The difference temporal lobe volume between male and female wasn't significant on the same side (F = 1.336, 0.127 ,P =0.249, 0.722).The left temporal lobe volumes of Group A-E were (93 873±13 351 ), (95 566±11 964), (10 1890±14 511 ), (93 972±14 050) and (95 636±19 864)mm3 respectively, and those on the right side were (93 409±10 984), (98 158±16 392), (102 079±15 112), (95 448±11 123 ) and (94 658±16 928) mm3.There were significant differences among 5 groups between left and right temporal lobe volume( F = 2.940, 3.514, P = 0.021, 0.008 ).Further pairwise comparison revealed that left and right temporal lobe volume in Group C is higher than those of Group A and D(P<0.05), while there were no significant differences between the other groups ( P > 0.05 ).Conclusion High-resolution MRI could offer detailed images and precise morphological data of temporal lobe, which provides morphological data of temporal lobe for the construction of database for Chinese Standard Brain.