| 蒙古族人群维生素D受体基因Fok Ⅰ多态性 |
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| 引用本文： | 邢少姬,周立社,许秀举. 蒙古族人群维生素D受体基因Fok Ⅰ多态性[J]. 中华医学遗传学杂志, 2006, 23(2): 236-237 |
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| 作者姓名： | 邢少姬 周立社 许秀举 |
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| 作者单位： | 014010,内蒙古自治区包头医学院基础医学部生物化学与分子生物学教研室 |
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| 摘 要： | 目的了解维生素D受体基因Fok Ⅰ多态性在蒙古族人群中的分布。方法应用聚合酶链反应一限制性片段长度多态性技术，分析506名内蒙古地区蒙古族人的维生素D受体Fok Ⅰ基因座的基因型和等位基因的分布频率。结果维生素D受体基因型FF、Ff、伍在本研究人群的分布频率分别为31％、52％和17％。等位基因F占57％，f占43％。基因型频率分布符合Hardy-Weinberg平衡定律。结论中国蒙古族人群维生素D受体基因Fok Ⅰ多态性分布频率有其自身的特点。
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| 关 键 词： | 维生素D受体 基因型 遗传多态性 |
Polymorphism of vitamin D receptor gene Fok Ⅰ in Mongolian population of China |
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| XING Shao-ji,ZHOU Li-she,XU Xiu-ju. Polymorphism of vitamin D receptor gene Fok Ⅰ in Mongolian population of China[J]. Chinese journal of medical genetics, 2006, 23(2): 236-237 |
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| Authors: | XING Shao-ji ZHOU Li-she XU Xiu-ju |
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| Affiliation: | Department of Biochemistry and Molecular Biology, Baotou Medical College, Baotou, Inner Mongolia, 014010 P.R.China. xingshaojihao@yahoo.com.cn |
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| Abstract: | OBJECTIVE: To investigate the polymorphism distribution of vitamin D receptor (VDR) gene Fok I in Mongolian population of China. METHODS: Polymerase chain reaction-restriction fragment length polymorphism (PCR-RFLP) method was used to analyze three genotypes FF, Ff and ff in the start codon of VDR gene (Fok I) in unrelated normal healthy Mongolian individuals of China. RESULTS: In the population, we obtained the allelic frequencies of 57% and 43% for (F) and (f) allele and the percentage of genotypes FF, Ff and ff to be 31%, 52%, and 17% respectively. CONCLUSION: The polymorphism frequency and distribution of this VDR gene Fok I in Mongolian population of China exhibit its own characteristics. |
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