| 国产沉香中1个新的2-(2-苯乙基)色酮 |
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| 引用本文： | 杨林,郭珮怡,郭顺星,戴均贵. 国产沉香中1个新的2-(2-苯乙基)色酮[J]. 中草药, 2016, 47(23): 4137-4140 |
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| 作者姓名： | 杨林 郭珮怡 郭顺星 戴均贵 |
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| 作者单位： | 中央民族大学生命与环境科学学院, 北京 100081;中央民族大学生命与环境科学学院, 北京 100081;中国医学科学院 北京协和医学院药用植物研究所, 北京 100193;中国医学科学院 北京协和医学院药物研究所, 北京 100050 |
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| 基金项目： | 国家自然科学基金资助项目（81573317）；建设世界一流大学（学科）和特色发展专项资金（YDZXXK201619） |
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| 摘 要： | 目的对国产沉香的小极性化学成分进行研究。方法运用硅胶、Sephadex LH-20、半制备高效液相等色谱方法进行分离纯化,并根据理化性质和波谱数据鉴定化合物的结构。结果从国产沉香的石油醚提取物中分离得到4个2-(2-苯乙基)色酮衍生物,分别鉴定为6-甲氧基-7-羟基-2-(2-苯乙基)色酮(1)、6,7-二甲氧基-2-(苯乙基)色酮(2)、6,7-二甲氧基-2-[2-(4′-甲氧基苯)乙基]色酮(3)、6-甲氧基-2-[2-(3′-甲氧基-4′-羟基苯)乙基]色酮(4)。结论化合物1为新化合物,命名为沉香酮J;化合物4为首次从国产沉香中分离得到。
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| 关 键 词： | 国产沉香 白木香 2-(2-苯乙基)色酮衍生物 沉香酮J 6-甲氧基-2-[2-(3''-甲氧基-4''-羟基苯)乙基] 色酮 |
| 收稿时间： | 2016-06-16 |
A new 2-(2-phenylethyl) chromone from Chinese eaglewood |
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| YANG Lin,GUO Pei-yi,GUO Shun-xing and DAI Jun-gui. A new 2-(2-phenylethyl) chromone from Chinese eaglewood[J]. Chinese Traditional and Herbal Drugs, 2016, 47(23): 4137-4140 |
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| Authors: | YANG Lin GUO Pei-yi GUO Shun-xing DAI Jun-gui |
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| Affiliation: | College of Life and Environmental Sciences, Minzu University of China, Beijing 100081, China;College of Life and Environmental Sciences, Minzu University of China, Beijing 100081, China;Institute of Medicinal Plant Development, Chinese Academy of Medical Sciences, Peking Union Medical College, Beijing 100193, China;Institute of Materia Medica, Chinese Academy of Medical Sciences, Peking Union Medical College, Beijing 100050, China |
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| Abstract: | Objective To study the chemical constituents of Chinese eaglewood.Methods The column chromatography on silica gel,Sephadex LH-20,and semi-preparative HPLC were used to separate and purify the compounds,their structures were elucidated by NMR and MS analyses.Results Four compounds were isolated from the petroleum ether of Chinese eaglewood and identified as 6-methoxy-7-hydroxy-2-(2-phenylethyl) chromone (1),6,7-dimethoxy-2-(2-phenylethyl) chromone (2),6,7-dimethoxy-2-[2-(4''-methoxyphenyl) ethyl]chromone (3),and 6-methoxy-2-[2-(3''-methoxy-4''-hydroxyphenyl) ethyl]chromone (4).Conclusion Compound 1 is a new compound named as Aquilarone J,and compound 4 is isolated from Chinese eaglewood for the first time. |
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| Keywords: | Chinese eaglewood Aquilaria sinensis (Lour.) Spreng. 2-(2-phenylethyl) chromone derivatives aquilarone J 6-methoxy-2-[2-(3''-methoxy-4''-hydroxyphenyl) ethyl]chromone |
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