妊娠妇女血清辅酶Q10水平与其新生儿出生体质量的关联性分析

目的：探讨妊娠妇女血清辅酶Q10（CoQ10）水平与新生儿体质量的关联性，阐明CoQ10对新生儿体质量的影响。方法：选取240例孕妇，应用酶联免疫吸附（ELISA）法测定孕妇血清CoQ10水平。根据新生儿体质量分为低体质量组、正常体质量组和巨大儿组，记录新生儿母亲血清CoQ10水平。根据产检妇女血清CoQ10第75百分位数分为CoQ10 ≥ 0.85μmol·L^-1组和CoQ10<0.85μmol·L^-1组，记录2组新生儿体质量。采用Spearman相关分析法分析孕妇血清CoQ10与新生儿体质量的相关性。结果：正常体质量组（0.91μmol·L^-1±0.41μmol·L^-1）和低体质量组（0.88μmol·L^-1±0.38μmol·L^-1）孕妇血清CoQ10水平高于巨大儿组（0.64μmol·^-1±0.23μmol·L^-1），差异有统计学意义（t=7.04，P<0.05；t=7.25，P<0.05）；孕妇血清CoQ10水平与新生儿体质量呈负相关关系（r=-0.17，P=0.00）。CoQ10 ≥ 0.85μmol·L^-1组新生儿出生体质量（3209.08g±320.15g）低于CoQ10<0.85μmol·L^-1组（3823.81g±189.04g），差异有统计学意义（P<0.05）。孕早期、孕晚期CoQ10水平和平均孕期CoQ10水平是影响新生儿体质量的因素（P<0.05或P<0.01）；孕早期、孕晚期CoQ10水平和平均孕期CoQ10水平是影响新生儿体质量的保护性因素（P<0.05）。结论：妊娠妇女血清CoQ10水平对其新生儿体质量有一定的影响。

Analysis on correlation between serum CoQ10 level of pregnant women and neonatal bady weight

Objective: To investigate the relationship between the serum levels of coenzyme Q10(CoQ10) of the pregnant women and the neonatal body weight, and to clarify the influence of CoQ10 in the neonatal body weight.Methods: A total of 240 pregnant women were selected.The serum CoQ10 levels of the pregnant women were detected by ELISA.According to the neonatal body weight, the newborn babies were dividied into low body weight group, normal body weight group and marcrosomia group; the maternal serum CoQ10 levels were recorded.According to the seventy-fifth percentile of serum CoQ10, the subjects were divided into CoQ10≥0.85 μmol·L^-1 group and CoQ10<0.85 μmol·L^-1 group. The neonatal body weights were recorded. The correlation between the maternal serum CoQ10 level and the neonatal body weight was analyzed with Spearman correlation analysis method.Results: The serum CoQ10 levels of pregnant women in normal body weight group (0.91 μmol·L^-1±0.41 μmol·L^-1) and low body weight group (0.88 μmol·L^-1±0.38 μmol·L^-1) were higher than that in macrosomia group (0.64 μmol·L^-1±0.23 μmol·L^-1), and the differences were statistically significant (t=7.04,P<0.05;t=7.25,P<0.05); the serum level of CoQ10 of pregnant women was negative correlated with the neonatal birth weight(r=-0.17,P=0.00). The neonatal birth weight in CoQ10≥0.85 μmol·L^-1group(3 209.08 g±320.15 g) was lower than that in CoQ10＜0.85 μmol·L^-1 group(3 823.81 g±189.04 g), the difference was statistically significant (P<0.05).The CoQ10 levels at early pregnancy and late pregnancy and ΔCoQ10 were the factors influencing the neonatal birth weight (P<0.05 or P<0.01);the CoQ10 levels at early pregnancy and late pregnancy and ΔCoQ10 were the protective factors to affect the neonatal birth weight(P<0.05).Conclusion: The level of serum CoQ10 of the pregnant women has effect on the body weights of their newborns